ArticleMicrobial cell factories2015
A novel process-based model of microbial growth: self-inhibition in Saccharomyces cerevisiae aerobic fed-batch cultures.
Article in Microbial cell factories, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Optimization of fermentation parameters for the valorization of tomato pomace into biomass to produce single cell protein using Saccharomyces cerevisiae.Bioresources and bioprocessing · 2026Article
- Extracellular Self-DNA Effects on Yeast Cell Cycle and Transcriptome during Batch Growth.Biomolecules · 2024Article
- Extracellular DNA secreted in yeast cultures is metabolism-specific and inhibits cell proliferation.Microbial cell (Graz, Austria) · 2023Article
- Article
- Metabolic flux analysis: a comprehensive review on sample preparation, analytical techniques, data analysis, computational modelling, and main application areas.RSC advances · 2022Review
- Rewiring the Metabolic Network to Increase Docosahexaenoic Acid Productivity inFrontiers in microbiology · 2022Article
- Article
- A cytofluorimetric analysis of a Saccharomyces cerevisiae population cultured in a fed-batch bioreactor.PloS one · 2021Article
- A General Process-Based Model for Describing the Metabolic Shift in Microbial Cell Cultures.Frontiers in microbiology · 2020Article
- Continuous Self-Cycling Fermentation Leads to Economical Lycopene Production byFrontiers in bioengineering and biotechnology · 2020Article
- Vegetable oils as carbon and energy source for Aureobasidium melanogenum in batch cultivation.MicrobiologyOpen · 2019Article
- Accelerated Bioprocess Development of Endopolygalacturonase-Production withBioengineering (Basel, Switzerland) · 2018Article
- Revisiting the Crabtree/Warburg effect in a dynamic perspective: a fitness advantage against sugar-induced cell death.Cell cycle (Georgetown, Tex.) · 2018Review
- Production of fatty acid-derived oleochemicals and biofuels by synthetic yeast cell factories.Nature communications · 2016Article
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Authors and funding
7 authors.
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Abstract
backgroundMicrobial population dynamics in bioreactors depend on both nutrients availability and changes in the growth environment. Research is still ongoing on the optimization of bioreactor yields focusing on the increase of the maximum achievable cell density.
resultsA new process-based model is proposed to describe the aerobic growth of Saccharomyces cerevisiae cultured on glucose as carbon and energy source. The model considers the main metabolic routes of glucose assimilation (fermentation to ethanol and respiration) and the occurrence of inhibition due to the accumulation of both ethanol and other self-produced toxic compounds in the medium. Model simulations reproduced data from classic and new experiments of yeast growth in batch and fed-batch cultures. Model and experimental results showed that the growth decline observed in prolonged fed-batch cultures had to be ascribed to self-produced inhibitory compounds other than ethanol.
conclusionsThe presented results clarify the dynamics of microbial growth under different feeding conditions and highlight the relevance of the negative feedback by self-produced inhibitory compounds on the maximum cell densities achieved in a bioreactor.
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