ArticleCerebral cortex (New York, N.Y. : 1991)2016
Subregional Mesiotemporal Network Topology Is Altered in Temporal Lobe Epilepsy.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Etiology-specific trajectories of longitudinal functional connectivity and network topology in posttraumatic and mesial temporal lobe epileptogenesis.Experimental neurology · 2026Article
- Distinct gray matter and metabolic characteristics in hypothalamic hamartoma network with different semiology.Epilepsia · 2025Article
- Frequency-band specific directed connectivity networks reveal functional disruptions and pathogenic patterns in temporal lobe epilepsy: a MEG study.Scientific reports · 2025Article
- Connectome reorganization associated with temporal lobe pathology and its surgical resection.Brain : a journal of neurology · 2024Article
- A WORLDWIDE ENIGMA STUDY ON EPILEPSY-RELATED GRAY AND WHITE MATTER COMPROMISE ACROSS THE ADULT LIFESPAN.bioRxiv : the preprint server for biology · 2024Article
- Distinguishing Patients with MRI-Negative Temporal Lobe Epilepsy from Normal Controls Based on Individual Morphological Brain Network.Brain topography · 2023Article
- In vivo characterization of magnetic resonance imaging-based T1w/T2w ratios reveals myelin-related changes in temporal lobe epilepsy.Human brain mapping · 2023Article
- Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression.Nature communications · 2022Article
- Structural Connectivity Alterations in Operculo-Insular Epilepsy.Brain sciences · 2021Article
- Temporal Lobe Epilepsy and Psychiatric Comorbidity.Frontiers in neurology · 2021Review
- Article
- Community-informed connectomics of the thalamocortical system in generalized epilepsy.Neurology · 2019Article
- WONOEP appraisal: Network concept from an imaging perspective.Epilepsia · 2019Review
- Neuroimaging correlates of language network impairment and reorganization in temporal lobe epilepsy.Brain and language · 2019Review
- The Principles of Electroconvulsive Therapy Based on Correlations of Schizophrenia and Epilepsy: A View From Brain Networks.Frontiers in neurology · 2019Review
- Temporal lobe epilepsy affects spatial organization of entorhinal cortex connectivity.Epilepsy & behavior : E&B · 2018Article
- Disrupted grey matter network morphology in pediatric posttraumatic stress disorder.NeuroImage. Clinical · 2018Article
- Multimodal imaging of language reorganization in patients with left temporal lobe epilepsy.Brain and language · 2017Article
- Increased MRI volumetric correlation contralateral to seizure focus in temporal lobe epilepsy.Epilepsy research · 2016Article
- Gray matter structural compromise is equally distributed in left and right temporal lobe epilepsy.Human brain mapping · 2016Article
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5 authors.
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Abstract
Temporal lobe epilepsy (TLE) is the most frequent drug-resistant epilepsy in adults and commonly associated with variable degrees of mesiotemporal atrophy on magnetic resonance imaging (MRI). Analyses of inter-regional connectivity have unveiled disruptions in large-scale cortico-cortical networks; little is known about the topological organization of the mesiotemporal lobe, the limbic subnetwork central to the disorder. We generated covariance networks based on high-resolution MRI surface-shape descriptors of the hippocampus, entorhinal cortex, and amygdala in 134 TLE patients and 45 age- and sex-matched controls. Graph-theoretical analysis revealed increased path length and clustering in patients, suggesting a shift toward a more regularized arrangement; findings were reproducible after split-half assessment and across 2 parcellation schemes. Analysis of inter-regional correlations and module participation showed increased within-structure covariance, but decreases between structures, particularly with regards to the hippocampus and amygdala. While higher clustering possibly reflects topological consequences of axonal sprouting, decreases in interstructure covariance may be a consequence of disconnection within limbic circuitry. Preoperative network parameters, specifically the segregation of the ipsilateral hippocampus, predicted long-term seizure freedom after surgery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.