ArticleCerebral cortex (New York, N.Y. : 1991)2016
High-Resolution Functional Connectivity Density: Hub Locations, Sensitivity, Specificity, Reproducibility, and Reliability.
Article in Cerebral cortex (New York, N.Y. : 1991), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 86 citations in OpenAlex.
- Neuromodulation and neural networks in psychiatric disorders: current status and emerging prospects.Psychological medicine · 2025Review
- Linking intrinsic brain dysfunction to behavioral outcomes in combat-exposed males with PTSD symptoms.Frontiers in psychiatry · 2025Article
- Genetic mechanisms of dynamic functional connectivity density in diabetic retinopathy brains: a combined transcriptomic and resting-state functional magnetic resonance imaging study.Frontiers in cellular neuroscience · 2025Article
- Molecular mechanisms underlying the neural correlates of working memory.BMC biology · 2024Article
- Global brain connectivity: Test-retest stability and association with biological and neurocognitive variables.Journal of neuroscience methods · 2024Article
- The brain network hub degeneration in Alzheimer's disease.Biophysics reports · 2024Article
- Audiovisual gamma stimulation for the treatment of neurodegeneration.Journal of internal medicine · 2024Review
- Functional connectivity density aberrance in type 2 diabetes mellitus with and without mild cognitive impairment.Frontiers in neurology · 2024Article
- Altered Density of Resting-State Long- and Short-Range Functional Connectivity in Patients with Moderate-to-Severe Obstructive Sleep Apnea.Nature and science of sleep · 2024Article
- Abnormal functional connectivity density involvement in freezing of gait and its application for subtyping Parkinson's disease.Brain imaging and behavior · 2023Article
- Psychological resilience mediates the protective role of default-mode network functional connectivity against COVID-19 vicarious traumatization.Translational psychiatry · 2023Article
- A 3D atlas of functional human brain energetic connectome based on neuropil distribution.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- True grit and brain: Trait grit mediates the connection of DLPFC functional connectivity density to posttraumatic growth following COVID-19.Journal of affective disorders · 2023Article
- Degree centrality and functional connections in presbycusis with and without cognitive impairments.Brain imaging and behavior · 2022Article
- Altered functional connectivity density and couplings in postpartum depression with and without anxiety.Social cognitive and affective neuroscience · 2022Article
- Disassociated and concurrent structural and functional abnormalities in the drug-naïve first-episode early onset schizophrenia.Brain imaging and behavior · 2022Article
- Characteristic functional cores revealed by hyperbolic disc embedding and k-core percolation on resting-state fMRI.Scientific reports · 2022Article
- Alterations in functional network centrality in first-episode drug-naïve adolescent-onset schizophrenia.Brain imaging and behavior · 2022Article
- Altered functional connectivity strength in chronic insomnia associated with gut microbiota composition and sleep efficiency.Frontiers in psychiatry · 2022Article
- Differential Abnormality in Functional Connectivity Density in Preclinical and Early-Stage Alzheimer's Disease.Frontiers in aging neuroscience · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Brain regions with high connectivity have high metabolic cost and their disruption is associated with neuropsychiatric disorders. Prior neuroimaging studies have identified at the group-level local functional connectivity density ( L: FCD) hubs, network nodes with high degree of connectivity with neighboring regions, in occipito-parietal cortices. However, the individual patterns and the precision for the location of the hubs were limited by the restricted spatiotemporal resolution of the magnetic resonance imaging (MRI) measures collected at rest. In this work, we show that MRI datasets with higher spatiotemporal resolution (2-mm isotropic; 0.72 s), collected under the Human Connectome Project (HCP), provide a significantly higher precision for hub localization and for the first time reveal L: FCD patterns with gray matter (GM) specificity >96% and sensitivity >75%. High temporal resolution allowed effective 0.01-0.08 Hz band-pass filtering, significantly reducing spurious L: FCD effects in white matter. These high spatiotemporal resolution L: FCD measures had high reliability [intraclass correlation, ICC(3,1) > 0.6] but lower reproducibility (>67%) than the low spatiotemporal resolution equivalents. GM sensitivity and specificity benchmarks showed the robustness of L: FCD to changes in model parameter and preprocessing steps. Mapping individual's brain hubs with high sensitivity, specificity, and reproducibility supports the use of L: FCD as a biomarker for clinical applications in neuropsychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.