Evidence map›Paper›PMID 26223227›Full record

Trial reportTrials2015

Negative pressure wound therapy use to decrease surgical nosocomial events in colorectal resections (NEPTUNE): study protocol for a randomized controlled trial.

Sami A Chadi, Kelly N Vogt, Sarah Knowles, Patrick B Murphy, Julie Ann Van Koughnett, Muriel Brackstone, Michael C Ott

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 4 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02007018 nacompletednot on this map

Negative Pressure Wound Therapy Use to Decrease Surgical Nosocomial Events in Colorectal Resections

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2015 to 2017Enrolled300ConditionsPostoperative Surgical Site InfectionsArmsNegative Pressure Wound Therapy, Usual Care of Surgical Wound
NCT03661814 naterminatednot on this mapstarted 2018, after this paper: background citation

Prophylactic Negative Pressure Wound Therapy to Reduce Surgical Site Infections in Elective Clean-Contaminated Colon Resections

TypeinterventionalSponsorIcahn School of Medicine at Mount SinaiRan2018 to 2019Enrolled7ConditionsSurgical Wound InfectionArmsPrevena
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 4 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Prophylactic closed-incision negative-pressure wound therapy is associated with decreased surgical site infection in high-risk colorectal surgery laparotomy wounds.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2019
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sami A ChadiDivision of General Surgery, Department of Surgery, University of Western Ontario, London, ON, Canada. samchadi@gmail.com.
Kelly N VogtDivision of General Surgery, Department of Surgery, University of Western Ontario, London, ON, Canada. kelly.vogt@lhsc.on.ca.
Sarah KnowlesDivision of General Surgery, Department of Surgery, University of Western Ontario, London, ON, Canada. sarah.knowles@londonhospitals.ca.
Patrick B MurphyDivision of General Surgery, Department of Surgery, University of Western Ontario, London, ON, Canada. patrick.murphy@londonhospitals.ca.
Julie Ann Van KoughnettDivision of General Surgery, Department of Surgery, University of Western Ontario, London, ON, Canada. julieann.vankoughnett@lhsc.on.ca.
Muriel BrackstoneDivision of General Surgery, Department of Surgery, University of Western Ontario, London, ON, Canada. muriel.brackstone@lhsc.on.ca.
Michael C OttDivision of General Surgery, Department of Surgery, University of Western Ontario, London, ON, Canada. michael.ott@lhsc.on.ca.
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurgical site infections (SSIs) are the second most common form of nosocomial infection. Colorectal resections have high rates of SSIs secondary to the inherently contaminated intraluminal environment. Negative pressure wound therapy dressings have been used on primarily closed incisions to reduce surgical site infections in other surgical disciplines. No randomized control trials exist to support the use of negative pressure wound therapy following elective open colorectal resection to reduce surgical site infection. METHODS/

designIn this single-center, superiority designed prospective randomized open blinded endpoint controlled trial, patients scheduled for a colorectal resection via a laparotomy will be considered eligible. Patients undergoing laparoscopic resection will be enrolled but only randomized and included if the operation is converted to an open procedure. Exclusion criteria are patients receiving an abdominoperineal resection or a palliative procedure, as well as pregnant patients and those with an adhesive allergy. After informed consent, 300 patients will be randomized to the use of a standard adhesive gauze dressing or to a negative pressure wound device. Patients will be followed in hospital and reassessed on post-operative day 30. The primary outcome measure is SSI within the first 30 post-operative days. Secondary outcomes include the length of hospital stay, the number of return visits related to a potential or actual SSI, cost, and the need for homecare. The primary endpoint analysis follows the intention-to-treat principle. DISCUSSION: NEPTUNE is the first randomized controlled trial to investigate the role of incisional negative pressure wound therapy in decreasing the rates of surgical site infections in the abdominal incisions of patients following an elective, open colorectal resection. This low-risk intervention may help decrease the morbidity and costs associated with the development of an SSI in our patients.

trial registrationNCT02007018--clinicaltrials.gov; 5 December 2013.

Indexed as

Negative-Pressure Wound TherapyClinical ProtocolsColonCross InfectionDigestive System Surgical ProceduresHome Care ServicesHospital CostsHumansIntention to Treat AnalysisLength of StayOntarioPatient ReadmissionProspective StudiesRectumResearch DesignRisk Factors

Identifiers

PMID26223227
PMCPMC4518608
OpenAlexW1918955267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.