Evidence map›Paper›PMID 26222906›Full record

SynthesisPloS one2015

Long-Term Diabetes Mellitus Is Associated with an Increased Risk of Pancreatic Cancer: A Meta-Analysis.

Shanshan Song, Baosheng Wang, Xin Zhang, Liliang Hao, Xianliang Hu, Zhongxiang Li, Shaolong Sun

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  19. Associations between Diabetes Mellitus and Selected Cancers.International journal of molecular sciences · 2024
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shanshan SongDepartment of Pancreas and Breast Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Baosheng WangDepartment of Pancreas and Breast Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Xin ZhangDepartment of Pancreas and Breast Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Liliang HaoDepartment of Pancreas and Breast Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Xianliang HuDepartment of Pancreas and Breast Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Zhongxiang LiDepartment of Pancreas and Breast Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Shaolong SunDepartment of Pancreas and Breast Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrevious studies have shown a bidirectional relationship between diabetes and pancreatic cancer (PC). In particular, new-onset diabetes might be induced by PC, and people with long-term diabetes might be at increased risk for the development of PC. The purpose of our study was to examine whether long-term diabetes represented an independent risk factor for PC development. METHODOLOGY: A literature search was performed by searching electronic databases for studies published before July 1, 2014, and relative risks (RRs) and corresponding 95% confidence intervals (CIs) were calculated. Data pertaining to diabetes were recorded at both individual and study levels, with RRs calculated separately to analyze the relationship between the duration of diabetes and the development of PC.

resultsForty-four studies were included in this meta-analysis, including 18 studies with a case-control design, 5 with a nested case-control design and 21 with a cohort design. The overall summary estimate for the relationship between the population with a duration of diabetes ≥2 years and PC was 1.64 (1.52-1.78). The pooled RR (95% CI) of PC for the population with a duration of diabetes ≥5 years was 1.58 (1.42-1.75). For the population with a duration of diabetes ≥10 years, the RR (95% CI) of PC was 1.50 (1.28-1.75).

conclusionsOur study suggests that long-term diabetes mellitus is associated with an increased risk of PC. However, the level of risk is negatively correlated with increasing diabetes mellitus duration.

Indexed as

AdultAgedAged, 80 and overCase-Control StudiesCohort StudiesDiabetes MellitusFemaleHumansMaleMiddle AgedPancreatic NeoplasmsRisk AssessmentRisk Factors

Identifiers

PMID26222906
PMCPMC4519136

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.