ArticlePloS one2015
Risk of Psychiatric Disorders following Irritable Bowel Syndrome: A Nationwide Population-Based Cohort Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- Psychopathological and neuropsychological disorders associated with chronic primary visceral pain: Systematic review.Frontiers in psychology · 2022Pooled it
- A meta-analysis and systematic review of the comorbidity between irritable bowel syndrome and bipolar disorder.Medicine · 2016Pooled it
- Prevalence of sleep disorder in irritable bowel syndrome: A systematic review with meta-analysis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationPooled it
- Effects of the antibiotic rifaximin on cortical functional connectivity are mediated through insular cortex.Scientific reports · 2021Trial
- Efficacy ofNutrients · 2020Trial
- Effectiveness of Anise Oil for Treatment of Mild to Moderate Depression in Patients With Irritable Bowel Syndrome: A Randomized Active and Placebo-Controlled Clinical Trial.Journal of evidence-based complementary & alternative medicine · 2017Trial
- Risk of uterine, ovarian and breast cancer following pelvic inflammatory disease: a nationwide population-based retrospective cohort study.BMC cancer · 2016Trial
- Beyond Chronic Stress: Daily Stress Is Associated With Symptoms in Irritable Bowel Syndrome.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Article
- Associations Between Irritable Bowel Syndrome, Depression, Anxiety, and Suicidal Ideation: a Partial Least Squares Path Analysis.The Psychiatric quarterly · 2026Article
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- Psychiatric Morbidity Following Intestinal Infectious Diseases: A Nationwide Cohort Study in South Korea.Stress and health : journal of the International Society for the Investigation of Stress · 2025Article
- Bipolar II disorder: a state-of-the-art review.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Prevalence of psychiatric disorders in patients of irritable bowel syndrome fulfilling Rome IV criteria: An observational study.Journal of family medicine and primary care · 2025Article
- Maladaptive weight control and eating behaviours in female adolescents/young adults are associated with increased risk of irritable bowel syndrome in adulthood: Results from the Growing Up Today Study (GUTS).Alimentary pharmacology & therapeutics · 2024Article
- A population-based study of familial coaggregation and shared genetic etiology of psychiatric and gastrointestinal disorders.Communications medicine · 2024Article
- Genetic associations and potential mediators between psychiatric disorders and irritable bowel syndrome: a Mendelian randomization study with mediation analysis.Frontiers in psychiatry · 2024Article
- Long-Term Implicit Epigenetic Stress Information in the Enteric Nervous System and its Contribution to Developing and Perpetuating IBS.Current neuropharmacology · 2024Review
- Bipolar II Disorder: Understudied and Underdiagnosed.Focus (American Psychiatric Publishing) · 2023Review
- Association between gut permeability, brain volume, and cognition in healthy participants and patients with schizophrenia spectrum disorder.Brain and behavior · 2023Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIrritable bowel syndrome (IBS) is the most common functional gastrointestinal (GI) disorder observed in patients who visit general practitioners for GI-related complaints. A high prevalence of psychiatric comorbidities, particularly anxiety and depressive disorders, has been reported in patients with IBS. However, a clear temporal relationship between IBS and psychiatric disorders has not been well established.
objectiveWe explored the relationship between IBS and the subsequent development of psychiatric disorders including schizophrenia, bipolar disorder, depressive disorder, anxiety disorder, and sleep disorder.
methodsWe selected patients who were diagnosed with IBS caused by gastroenteritis, according to the data in the Taiwan National Health Insurance Research Database. A comparison cohort was formed of patients without IBS who were matched according to age and sex. The incidence rate and the hazard ratios (HRs) of subsequent new-onset psychiatric disorders were calculated for both cohorts, based on psychiatrist diagnoses.
resultsThe IBS cohort consisted of 4689 patients, and the comparison cohort comprised 18756 matched control patients without IBS. The risks of depressive disorder (HR = 2.71, 95% confidence interval [CI] = 2.30-3.19), anxiety disorder (HR = 2.89, 95% CI = 2.42-3.46), sleep disorder (HR = 2.47, 95% CI = 2.02-3.02), and bipolar disorder (HR = 2.44, 95% CI = 1.34-4.46) were higher in the IBS cohort than in the comparison cohort. In addition, the incidence of newly diagnosed depressive disorder, anxiety disorder, and sleep disorder remained significantly increased in all of the stratified follow-up durations (0-1, 1-5, ≥5 y).
conclusionsIBS may increase the risk of subsequent depressive disorder, anxiety disorder, sleep disorder, and bipolar disorder. The risk ratios are highest for these disorders within 1 year of IBS diagnosis, but the risk remains statistically significant for more than 5 years. Clinicians should pay particular attention to psychiatric comorbidities in IBS patients.
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