ArticlePloS one2015
Systematic Analysis of the Molecular Mechanism Underlying Decidualization Using a Text Mining Approach.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Disruption of primary ciliary prostaglandin EJournal of biomedical science · 2026Article
- Identification of CXCL12 as a key gene of trophoblast and endometrial stromal cell decidualization in pregnancy via scRNA-seq and experimental validation.Frontiers in molecular biosciences · 2026Article
- Fetal growth restriction and placental defects in obese mice are associated with impaired decidualisation: the role of increased leptin signalling modulators SOCS3 and PTPN2.Cellular and molecular life sciences : CMLS · 2024Article
- Uterine deficiency of Dnmt3b impairs decidualization and causes consequent embryo implantation defects.Cell biology and toxicology · 2023Article
- Identification of Intercellular Crosstalk between Decidual Cells and Niche Cells in Mice.International journal of molecular sciences · 2021Article
- Preimplantation factor modulates trophoblastic invasion throughout the decidualization of human endometrial stromal cells.Reproductive biology and endocrinology : RB&E · 2021Article
- Article
- Endometrial Decidualization: The Primary Driver of Pregnancy Health.International journal of molecular sciences · 2020Review
- Bioinformatic analysis of the molecular mechanism underlying bronchial pulmonary dysplasia using a text mining approach.Medicine · 2019Article
- Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy.PLoS biology · 2019Article
- Genome-Wide Association Mapping for Female Infertility in Inbred Mice.G3 (Bethesda, Md.) · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decidualization is a crucial process for successful embryo implantation and pregnancy in humans. Defects in decidualization during early pregnancy are associated with several pregnancy complications, such as pre-eclampsia, intrauterine growth restriction and recurrent pregnancy loss. However, the mechanism underlying decidualization remains poorly understood. In the present study, we performed a systematic analysis of decidualization-related genes using text mining. We identified 286 genes for humans and 287 genes for mice respectively, with an overlap of 111 genes shared by both species. Through enrichment test, we demonstrated that although divergence was observed, the majority of enriched gene ontology terms and pathways were shared by both species, suggesting that functional categories were more conserved than individual genes. We further constructed a decidualization-related protein-protein interaction network consisted of 344 nodes connected via 1,541 edges. We prioritized genes in this network and identified 12 genes that may be key regulators of decidualization. These findings would provide some clues for further research on the mechanism underlying decidualization.
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Registered trials
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