ArticleKidney international2015
National trends in acute kidney injury requiring dialysis in England between 1998 and 2013.
Article in Kidney international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02675296 (Regional and Long Term Outcomes of Acute Kidney Injury in England From 2000 to 2015 - A National Database Study), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Regional and Long Term Outcomes of Acute Kidney Injury in England From 2000 to 2015 - A National Database Study
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of early dialysis on the outcomes of critically ill patients with acute kidney injury: a systematic review and meta-analysis of randomized controlled trials.Scientific reports · 2019Pooled it
- Outcomes In Acute Kidney Injury Requiring Haemodialysis - A Retrospective Cohort Study.The Ulster medical journal · 2025Article
- Temporal Trends in Acute Kidney Injury in Hospitalizations From 2009-2018 in Alberta: A Retrospective Population-Based Cohort Study.Kidney medicine · 2025Article
- Development and validation of a prediction model for 90-day mortality among critically ill patients with AKI undergoing CRRT.Journal of nephrology · 2025Article
- Predictive enrichment for the need of renal replacement in sepsis-associated acute kidney injury: combination of furosemide stress test and urinary biomarkers TIMP-2 and IGFBP-7.Annals of intensive care · 2024Article
- Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data.BMC infectious diseases · 2024Observational
- Risk of adverse events following the initiation of antihypertensives in older people with complex health needs: a self-controlled case series in the United Kingdom.Age and ageing · 2023Article
- Tea Consumption and New-Onset Acute Kidney Injury: The Effects of Milk or Sweeteners Addition and Caffeine/Coffee.Nutrients · 2023Article
- Specificity of severe AKI aetiology and care in the elderly. The IRACIBLE prospective cohort study.Journal of nephrology · 2022Article
- Observational
- Results of the 2018 Japan Society for Blood Purification in Critical Care survey: current status and outcomes.Renal replacement therapy · 2022Article
- When and why to start continuous renal replacement therapy in critically ill patients with acute kidney injury.Kidney research and clinical practice · 2021Article
- Prognostic Performance of Existing Scoring Systems among Critically Ill Patients Requiring Continuous Renal Replacement Therapy: An Observational Study.Journal of clinical medicine · 2021Article
- Target value of mean arterial pressure in patients undergoing continuous renal replacement therapy due to acute kidney injury.BMC nephrology · 2021Article
- Disease Mechanisms of Perioperative Organ Injury.Anesthesia and analgesia · 2020Review
- Survival and renal recovery after acute kidney injury requiring dialysis outside of intensive care units.International urology and nephrology · 2020Article
- Pulsed focused ultrasound enhances the therapeutic effect of mesenchymal stromal cell-derived extracellular vesicles in acute kidney injury.Stem cell research & therapy · 2020Article
- Reversing Acute Kidney Injury Using Pulsed Focused Ultrasound and MSC Therapy: A Role for HSP-Mediated PI3K/AKT Signaling.Molecular therapy. Methods & clinical development · 2020Article
- US Trends in Hospitalizations for Dialysis-Requiring Acute Kidney Injury in People With Versus Without Diabetes.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2020Article
- Feasibility of coding-based Charlson comorbidity index for hospitalized patients in China, a representative developing country.BMC health services research · 2020Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI) severe enough to require dialysis is increasing and associated with high mortality, yet robust information about temporal epidemiology of AKI requiring dialysis in England is lacking. In this retrospective observational study of the Hospital Episode Statistics (HES) data set covering the entire English National Health Service, we identified all patients with a diagnosis of AKI requiring dialysis between 1998 and 2013. This incidence increased from 774 cases (15.9 per million people) in 1998-1999 to 11,164 cases (208.7 per million people) in 2012-2013. The unadjusted in-hospital case-fatality was 30.3% in 1998-2003 and 30.2% in 2003-2008, but significantly increased to 41.1% in 2008-2013. Compared with 2003-2008, the multivariable adjusted odds ratio for death was higher in 1998-2003 at 1.20 (95% CI: 1.10-1.30) and in 2008-2013 at 1.13 (1.07-1.18). Charlson comorbidity scores of more than five (odds ratio 2.35; 95% CI: 2.20-2.51) and emergency admissions (2.46 (2.32-2.61) had higher odds for death. The odds for death decreased in patients over 85 years from 4.83 (3.04-7.67) in 1998-2003 to 2.19 (1.99-2.41) in 2008-2013. AKI in secondary diagnosis and in other diagnoses codes had higher odds for death compared with AKI in primary diagnosis code in all three periods. Thus, the incidence of AKI requiring dialysis has increased progressively over 15 years in England. Improvement in case-fatality in 2003-2008 has not been sustained in the last 5 years.
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