ArticlePloS one2015
Feasibility of a Short-Arm Centrifuge for Mouse Hypergravity Experiments.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Granular flow experiment using artificial gravity generator at International Space Station.NPJ microgravity · 2023Article
- The importance of gravity vector on adult mammalian organisms: Effects of hypergravity on mouse testis.PloS one · 2023Article
- Antibiotics and the Nervous System-Which Face of Antibiotic Therapy Is Real, Dr. Jekyll (Neurotoxicity) or Mr. Hyde (Neuroprotection)?Molecules (Basel, Switzerland) · 2021Review
- Effects of microgravity exposure and fructo-oligosaccharide ingestion on the proteome of soleus and extensor digitorum longus muscles in developing mice.NPJ microgravity · 2021Article
- Study of mouse behavior in different gravity environments.Scientific reports · 2021Article
- Review
- Understanding vestibular-related physiological functions could provide clues on adapting to a new gravitational environment.The journal of physiological sciences : JPS · 2020Review
- Roles of the vestibular system in obesity and impaired glucose metabolism in high-fat diet-fed mice.PloS one · 2020Article
- The effects of simulated +Gz and microgravity on intervertebral disc degeneration in rabbits.Scientific reports · 2019Article
- Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight.Microbiome · 2019Article
- An instrumented centrifuge for studying mouse locomotion and behaviour under hypergravity.Biology open · 2019Article
- Hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice.Scientific reports · 2019Article
- Dietary intervention of mice using an improved Multiple Artificial-gravity Research System (MARS) under artificial 1NPJ microgravity · 2019Article
- Effects of hypergravity on gene levels in anti-gravity muscle and bone through the vestibular system in mice.The journal of physiological sciences : JPS · 2018Article
- Development of new experimental platform 'MARS'-Multiple Artificial-gravity Research System-to elucidate the impacts of micro/partial gravity on mice.Scientific reports · 2017Article
- Food matters: how the microbiome and gut-brain interaction might impact the development and course of anorexia nervosa.European child & adolescent psychiatry · 2017Review
- Impact of a simulated gravity load for atmospheric reentry, 10 g for 2 min, on conscious mice.The journal of physiological sciences : JPS · 2017Article
- International roadmap for artificial gravity research.NPJ microgravity · 2017Review
- Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain.PloS one · 2017Article
- A hypergravity environment increases chloroplast size, photosynthesis, and plant growth in the moss Physcomitrella patens.Journal of plant research · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To elucidate the pure impact of microgravity on small mammals despite uncontrolled factors that exist in the International Space Station, it is necessary to construct a 1 g environment in space. The Japan Aerospace Exploration Agency has developed a novel mouse habitat cage unit that can be installed in the Cell Biology Experiment Facility in the Kibo module of the International Space Station. The Cell Biology Experiment Facility has a short-arm centrifuge to produce artificial 1 g gravity in space for mouse experiments. However, the gravitational gradient formed inside the rearing cage is larger when the radius of gyration is shorter; this may have some impact on mice. Accordingly, biological responses to hypergravity induced by a short-arm centrifuge were examined and compared with those induced by a long-arm centrifuge. Hypergravity induced a significant Fos expression in the central nervous system, a suppression of body mass growth, an acute and transient reduction in food intake, and impaired vestibulomotor coordination. There was no difference in these responses between mice raised in a short-arm centrifuge and those in a long-arm centrifuge. These results demonstrate the feasibility of using a short-arm centrifuge for mouse experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.