Evidence map›Paper›PMID 26221618›Full record

ArticleReceptors & clinical investigation

Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors.

Yeon Sun Lee, Sara M Hall, Cyf Ramos-Colon, Michael Remesic, David Rankin, Todd W Vanderah, Frank Porreca, Josephine Lai, Victor J Hruby

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Receptors & clinical investigation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yeon Sun LeeDepartment of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, USA.
Sara M HallDepartment of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, USA.
Cyf Ramos-ColonDepartment of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, USA.
Michael RemesicDepartment of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, USA.
David RankinDepartment of Pharmacology, The University of Arizona, Tucson, AZ 85721, USA.
Todd W VanderahDepartment of Pharmacology, The University of Arizona, Tucson, AZ 85721, USA.
Frank PorrecaDepartment of Pharmacology, The University of Arizona, Tucson, AZ 85721, USA.
Josephine LaiDepartment of Pharmacology, The University of Arizona, Tucson, AZ 85721, USA.
Victor J HrubyDepartment of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, USA.
University of Arizona · US

Funding

THERAPEUTIC PROFILES OF OPIOID DELTA RECEPTORS--NEW MODALITIESP01DA006284 · NIDA · UNIVERSITY OF ARIZONA · PI HRUBY, VICTOR J · 1989 to 2015
$14.8M
NOVEL NON-PEPTIDE OPIOID LIGANDS FOR PAINR01DA013449 · NIDA · UNIVERSITY OF ARIZONA · PI HRUBY, VICTOR J · 2000 to 2015
$6.8M
NIDA NIH HHS P01 DA006284NIDA NIH HHS R01 DA013449
6 · The paper itself

Abstract

Dynorphin A (Dyn A) is an endogenous opioid ligand that possesses neuroinhibitory (antinociceptive) effects via μ, δ, and κ opioid receptors. However, under chronic pain conditions, up-regulated spinal Dyn A can also interact with bradykinin receptors (BRs) to promote hyperalgesia through a neuroexcitatory(pronociceptive) effect. These excitatory effects cannot be blocked by an opioid antagonist, and thus are non-opioid in nature. On the basis of the structural dissimilarity between Dyn A and endogenous BR ligands, bradykinin(BK) and kallidin (KD), Dyn A's interaction with BRs could not be predicted, and provided an opportunity to identify a novel potential neuroexcitatory target. Systematic structure-activity relationship (SAR) studies discovered a minimum pharmacophore of Dyn A, [des-Arg

Identifiers

PMID26221618
PMCPMC4515361
OpenAlexW1820002405

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.