ArticleBrain and behavior2015
Left hippocampus-amygdala complex macro- and microstructural variation is associated with BDNF plasma levels in healthy elderly individuals.
Article in Brain and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Whole-Brain Vascular Architecture Mapping Identifies Region-Specific Microvascular Profiles In Vivo.AJNR. American journal of neuroradiology · 2024Article
- An Increased Aspartate to Alanine Aminotransferase Ratio Is Associated With a Higher Risk of Cognitive Impairment.Frontiers in medicine · 2022Article
- Glutamine + glutamate level predicts the magnitude of microstructural organization in the gray matter in the healthy elderly.International psychogeriatrics · 2021Article
- Brain-derived neurotrophic factor association with amygdala response in major depressive disorder.Journal of affective disorders · 2020Article
- Article
- The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice.Scientific reports · 2018Article
- Longitudinal epigenetic predictors of amygdala:hippocampus volume ratio.Journal of child psychology and psychiatry, and allied disciplines · 2017Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDeep brain gray matter (GM) structures are involved in several neurodegenerative disorders and are affected by aging. In this study, we investigated the potential relationship between levels of brain-derived neurotrophic factor (BDNF), a putative biomarker of age- and clinically relevant brain dysfunctions, and the presence of structural modifications that were evaluated by magnetic resonance imaging in six deep GM structures.
methodsVolume changes and diffusion tensor imaging (DTI) scalars were studied in the thalamus, putamen, hippocampus, caudate nucleus, amygdala and pallidum of a cohort of 120 healthy subjects. The cohort included young (18-39 years old), adult (40-59 years old) and elderly (60-76 years old) subjects.
resultsNo correlations were seen in the young and adult cohorts. In the elderly group, we observed reduced BDNF levels that correlated with increased DTI-based mean diffusivity occurring in the left hippocampus along with decreased normalized volume in the left amygdala.
conclusionsThese findings suggest that, in elderly subjects, BDNF may exert regional and lateralized effects that allow the integrity of two strategic deep GM areas such as the hippocampus and the amygdala.
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