ArticleJournal of diabetes investigation2015
Effects of chromium malate on glycometabolism, glycometabolism-related enzyme levels and lipid metabolism in type 2 diabetic rats: A dose-response and curative effects study.
Article in Journal of diabetes investigation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Chromium restriction in the intrauterine environment and development of metabolic diseases in mice offspring.Journal of Taibah University Medical Sciences · 2025Article
- Nutrient Adequacy in Endurance Athletes.International journal of environmental research and public health · 2023Article
- Preparation and hypoglycemic effects of chromium- and zinc-richWorld journal of diabetes · 2022Article
- The Effect and Potential Mechanism of Maternal Micronutrient Intake on Offspring Glucose Metabolism: An Emerging Field.Frontiers in nutrition · 2021Review
- Prevalence and Risk Factors of Type 2 Diabetes and Prediabetes Among 53,288 Middle-Aged and Elderly Adults in China: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Typical neurobehavioral methods and transcriptome analysis reveal the neurotoxicity and mechanisms of di(2-ethylhexyl) phthalate on pubertal male ICR mice with type 2 diabetes mellitus.Archives of toxicology · 2020Article
- Effect of type 2 diabetes mellitus caveolin-3 K15N mutation on glycometabolism.Experimental and therapeutic medicine · 2019Article
- Maternal chromium restriction induces insulin resistance in adult mice offspring through miRNA.International journal of molecular medicine · 2018Article
- Article
- Maternal chromium restriction modulates miRNA profiles related to lipid metabolism disorder in mice offspring.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- The effect of maternal chromium status on lipid metabolism in female elderly mice offspring and involved molecular mechanism.Bioscience reports · 2017Article
- Article
- Maternal Chromium Restriction Leads to Glucose Metabolism Imbalance in Mice Offspring through Insulin Signaling and Wnt Signaling Pathways.International journal of molecular sciences · 2016Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS/
introductionThe present study was designed to evaluate the effect of chromium malate on glycometabolism, glycometabolism-related enzyme levels and lipid metabolism in type 2 diabetic rats, and dose-response and curative effects. MATERIALS AND
methodsThe model of type 2 diabetes rats was developed, and daily treatment with chromium malate was given for 4 weeks. A rat enzyme-linked immunosorbent assay kit was used to assay glycometabolism, glycometabolism-related enzyme levels and lipid metabolism changes.
resultsThe results showed that the antihyperglycemic activity increased with administration of chromium malate in a dose-dependent manner. The serum insulin level, insulin resistance index and C-peptide level of the chromium malate groups at a dose of 17.5, 20.0 and 20.8 μg chromium/kg bodyweight were significantly lower than that of the model, chromium trichloride and chromium picolinate groups. The hepatic glycogen, glucose-6-phosphate dehydrogenase and glucokinase levels of the chromium malate groups at a dose of 17.5, 20.0 and 20.8 μg chromium/kg bodyweight were significantly higher than that of the model, chromium trichloride and chromium picolinate groups. Chromium malate at a dose of 20.0 and 20.8 μg chromium/kg bodyweight significantly changed the total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides levels compared with the chromium trichloride and chromium picolinate groups.
conclusionsThe results showed that chromium malate exhibits greater benefits in treating type 2 diabetes, and the curative effect of chromium malate is superior to chromium trichloride and chromium picolinate.
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