Evidence map›Paper›PMID 26221511›Full record

ArticleCaspian journal of internal medicine2015

The effect of resveratrol on the expression of MDR1 gene in leukemic lymphoblast's of acute lymphoblastic leukemia patients.

Abbas Ali Hosein Poor Feyzi, Majid Farshdousti Hagh, Tohid Ebadi, Karim Shams Asanjan, Aliakbar Movasagpoor Akbari, Mehdi Talebi, Behzad Emadi

Open access · greenAbstract read
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In one paragraph

Article in Caspian journal of internal medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Abbas Ali Hosein Poor FeyziHematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Majid Farshdousti HaghHematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Tohid EbadiDepartment of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Karim Shams AsanjanDepartment of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Aliakbar Movasagpoor AkbariDepartment of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Mehdi TalebiDepartment of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Behzad EmadiDepartment of Microbiology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran.
Tabriz University of Medical Sciences · IRIran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChemotherapy plays a very important role in the treatment of leukemia but the resistance properties of the lymphoblasts limit the effect of chemotherapy. One of the main mechanisms of resistance to chemotherapy is the increased expression of MDR1 gene. The aim of this study was to explore the effect of resveratrol on the expression of MDR1 gene in leukemic lymphoblast of new cases of acute lymphoblastic leukemia (ALL) patients in vitro.

methodsSeparation of lymphoblasts of 5 new case ALL patients from peripheral blood was performed by ficoll density gradient centrifugation. Lymphoblasts were cultured in RPMI 1640 medium. Lymphoblasts were treated with 50µmol/L resveratrol for 48 h. Total RNA was extracted with guanidine isothiocyanate. RNA was converted to cDNA. Real time PCR was used to detect mRNA expression of MDR1.

resultsThe results of gene detection showed that the expression of MDR1 did not change significantly in the patients however, in one patient expression of MDR1 increased upon treatment with resveratrol.

conclusionThe results of this study did not support resveratrol as a compound to reverse multidrug resistance in leukemic lymphoblasts.

Indexed as

ALLLeukemic lymphoblastMultidrug resistance geneResveratrol

Identifiers

PMID26221511
PMCPMC4478462
OpenAlexW1631167719

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.