Evidence map›Paper›PMID 26221490›Full record

ArticleCaspian journal of internal medicine2015

Human papilloma virus infection in non-cancerous versus normal esophageal tissue samples by endoscopy.

Narges Mostafalou, Yousef Yahyapour, Sadegh Sedaghat, Javad Shokri Shirvani, Mahmoud HajiAhmadi, Sepideh Siadati, Shahriar Shafaei

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In one paragraph

Article in Caspian journal of internal medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Narges MostafalouDepartment of Internal Medicine, Babol University of Medical Sciences, Babol, Iran.
Yousef YahyapourInfectious Diseases & Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran.
Sadegh SedaghatDepartment of Internal Medicine, Babol University of Medical Sciences, Babol, Iran.
Javad Shokri ShirvaniDepartment of Internal Medicine, Babol University of Medical Sciences, Babol, Iran.
Mahmoud HajiAhmadiDepartment of Biostatistics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Sepideh SiadatiDepartment of Pathology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Shahriar ShafaeiDepartment of Pathology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Babol University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancers are the second most common cause of non-accidental deaths in Iran, after cardiovascular mortality. Although most cases of esophageal squamous cell carcinoma (ESCC) in the USA and western populations have been attributed to high levels of exposure to tobacco and alcohol, but in Iranian populations, other risk factors especially infectious agents have been postulated as possible causes, particularly human papillomavirus (HPV). This study aimed to determine the prevalence and the types of HPV infection in biopsy samples taken from non-cancerous esophageal lesions during upper endoscopy.

methodsA total of 80 non-cancerous esophageal samples were collected in parafinnated blocks of tissue archives in pathology. After DNA extraction, qualitative PCR (qPCR) was performed using the HPV L1 primer pairs MY09/MY11 and then genotyping was performed in HPV DNA positive by Real time PCR.

resultsFrom 80 cases, 29 (36.3%) were qPCR positive. Using the Real-time PCR method, a total of 14 HPV genotypes were assessed. We detected HPV-11 as a dominant type in this study and we did not find any type of HPV-16 and 18 genotypes.

conclusionIn this study, HPV-II was the most common type in esophageal samples, in contrast we have found no oncogenic HPV like HPV 16 and 18 which are the most known responsible factors of ESCC in other countries.

Indexed as

esophagitisHPV (Human Papilloma virus)normal tissue; non-cancerReal-Time PCR.

Identifiers

PMID26221490
PMCPMC4478112
OpenAlexW1855067267

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.