ArticleInternational journal of clinical and experimental medicine2015
Chronic myeloid leukemia transformation in a patient with paroxysmal nocturnal hemoglobinuria: a rare case report with literature review.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Discovery of a second, distinct development pattern of leukemic conversion from paroxysmal nocturnal hemoglobinuria.International journal of hematology · 2025Review
- Paroxysmal Nocturnal Hemoglobinuria in the Context of a Myeloproliferative Neoplasm: A Case Report and Review of the Literature.Frontiers in oncology · 2021Article
- Article
- Abnormal expression and mutation of the RBPJ gene may be involved in CD59Experimental and therapeutic medicine · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic stem cell (HSC) disorder arising from a somatic mutation of the X-linked phosphatidylinositol glycan complementation class A gene (PIG-A) which leads to partial or complete deficiency of glycosyl-phosphatidylinositol (GPI)-linked membrane proteins and causes intravascular hemolysis. Its pathophysiological links with aplastic anemia (AA) and myelodysplastic syndrome (MDS) have been described frequently, and few acute leukemia are proved to be derived from PNH. However, PNH with transformation to chronic myeloid leukemia (CML) has never been reported. Here, we report a patient initially diagnosed with PNH while 11 years later, Ph chromosome and BCR/ABL fusion gene were detected and the patient was eventually confirmed the diagnosis of CML. Here, the diagnosis and management of the interesting case, as well as questions regarding pathogenesis, are discussed.
Indexed as
Identifiers
26221399PMC4509344W1091970467What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.