ArticleInternational journal of clinical and experimental medicine2015
Progesterone reduces inflammation and apoptosis in neonatal rats with hypoxic ischemic brain damage through the PI3K/Akt pathway.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Progesterone for acute traumatic brain injury.The Cochrane database of systematic reviews · 2016Pooled it
- [Gastrodin alleviates microglia-mediated inflammatory responses in neonatal mice with hypoxic-ischemic brain damage by regulating CCR5/AKT signaling].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Gastrodin Regulates PI3K/AKT-Sirt3 Signaling Pathway and Proinflammatory Mediators in Activated Microglia.Molecular neurobiology · 2024Article
- Evaluating the neuroprotective effects of progesterone receptors on experimental traumatic brain injury: The PI3K/Akt pathway.Brain and behavior · 2023Article
- The "double-edged" role of progesterone in periodontitis among perimenopausal women undergoing or not undergoing scaling and root planing.Frontiers in endocrinology · 2023Article
- Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions.Signal transduction and targeted therapy · 2022Review
- Article
- Toll-Like Receptor Signaling Pathways: Novel Therapeutic Targets for Cerebrovascular Disorders.International journal of molecular sciences · 2021Review
- Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.Experimental and therapeutic medicine · 2021Article
- κ‑opioid receptor agonist U50488H attenuates postoperative cognitive dysfunction of cardiopulmonary bypass rats through the PI3K/AKT/Nrf2/HO‑1 pathway.Molecular medicine reports · 2021Article
- Long-Lasting Actions of Progesterone Protect the Neonatal Brain Following Hypoxia-Ischemia.Cellular and molecular neurobiology · 2020Article
- Up-regulation of miR-146b-3p protects septic mice with acute respiratory distress syndrome by inhibiting PI3K/AKT signaling pathway.Journal of bioenergetics and biomembranes · 2020Article
- Yizhi Qingxin Formula Extract Ameliorates Cognitive Decline in Aged RatsFrontiers in pharmacology · 2020Article
- The regulatory role of Toll-like receptors after ischemic stroke: neurosteroids as TLR modulators with the focus on TLR2/4.Cellular and molecular life sciences : CMLS · 2019Review
- Retinoic acid receptor α expression exerts an anti-apoptosis effect on PC12 cells following oxygen-glucose deprivation.Experimental and therapeutic medicine · 2018Article
- Relationships between low-grade peripheral inflammation and psychotropic drugs in schizophrenia: results from the national FACE-SZ cohort.European archives of psychiatry and clinical neuroscience · 2018Article
- Effects of progesterone on the neonatal brain following hypoxia-ischemia.Metabolic brain disease · 2018Article
- p53 Mediates Colistin-Induced Autophagy and Apoptosis in PC-12 Cells.Antimicrobial agents and chemotherapy · 2016Article
- Down-regulated Na(+)/K(+)-ATPase activity in ischemic penumbra after focal cerebral ischemia/reperfusion in rats.International journal of clinical and experimental pathology · 2015Article
- Hormone replacement therapy reduces lipid oxidation directly at the arterial wall: A possible link to estrogens' cardioprotective effect through atherosclerosis prevention.Journal of mid-life healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A neonatal rat model with hypoxic ischemic brain damage (HIBD) was established. Forty 7-day-old neonatal Wistar rats were randomly divided into four groups: sham operation, model, progesterone and Akt inhibitor. Electron microscopy revealed that the neonatal rats with HIBD showed neuronal changes. The protein expression levels of pAkt, Nuclear factor κB (NF-κB) and Bcl-2 in the hippocampus were detected by immunohistochemistry and Western blot. The neuronal structure was normal in the sham operation group after HIBD for 24 h. Cavitation change due to hypoxic ischemic brain damage was observed in the neurons of the model group. Progesterone treatment improved neuronal damage and cavitation. Neuronal cavitation was clearly changed in the Akt inhibitor group. The protein expression levels of hippocampal pAkt and Bcl-2 did not significantly change after HIBD, whereas that of NF-κB increased. Progesterone pre-treatment increased the expression levels of pAkt and Bcl-2 but decreased that of NF-κB. The protein expression levels of pAkt and Bcl-2 decreased in the Akt inhibitor group, whereas that of NF-κB increased. This result indicates that progesterone can decrease inflammation in HIBD, inhibit apoptosis and protect the brain by activating the Phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signalling pathway.
Indexed as
Identifiers
26221393PMC4509338W2193639688What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.