ArticleInternational journal of clinical and experimental medicine2015
Association analysis of genetic variants of adiponectin gene and risk of pancreatic cancer.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- AdipoRon and Pancreatic Ductal Adenocarcinoma: a future perspective in overcoming chemotherapy-induced resistance?Cancer drug resistance (Alhambra, Calif.) · 2022Article
- Role of the microbiome in occurrence, development and treatment of pancreatic cancer.Molecular cancer · 2019Review
- Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic AdenocarcinomaAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Pancreatic cancer associated with obesity and diabetes: an alternative approach for its targeting.Journal of experimental & clinical cancer research : CR · 2018Review
- ADIPOQ rs266729 G/C gene polymorphism and plasmatic adipocytokines connect metabolic syndrome to colorectal cancer.Journal of Cancer · 2017Article
- Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancer.World journal of gastroenterology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adiponectin is a cytokine exclusively secreted from adipocyte, and could perform direct or indirect effects on anti-inflammation and anti-tumor. Previous researches have studied the correlation between plasma adiponectin levels and the risk of pancreatic cancer. So we aimed at investigating the association of genetic variants of adiponectin gene and the risk of pancreatic cancer. In this study, we genotyped 6 SNPs of adiponectin gene in a case-control study of recruited 172 patients of pancreatic cancer and 181 healthy people in Chinese Han population. The results indicated that two of the SNPs had significant associations with pancreatic cancer. Of which, the SNP rs1501299C>A decreased the risk of PC (P=0.016, OR=0.662 95% CI 0.472-0.928), while rs1065358T>C increased the risk of PC (P=0.027, OR=1.421 95% CI 1.040-1.941). Furthermore, in the clinical correlation analysis, we found rs1501299 was correlated with tumor size (P=0.026), cigarette smoking (P=0.022) and alcohol consumption (P=0.001) and rs1063538 was correlated with alcohol consumption (P=0.026). In conclusion, we provided evidences that the variants in adiponectin gene might influence the development and progression of pancreatic cancer.
Indexed as
Identifiers
26221375PMC4509320What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.