ArticleInternational journal of clinical and experimental medicine2015
Anxiety and depression are associated with increased counts and degranulation of duodenal mast cells in functional dyspepsia.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Second Asian Consensus Report on Functional Dyspepsia (2025): Updated Recommendations.Journal of gastroenterology and hepatology · 2026Pooled it
- A Meta-Analysis of Observational Studies on the Association of Chronic Urticaria With Symptoms of Depression and Anxiety.Frontiers in medicine · 2020Pooled it
- A Pilot Study of Ketotifen in Patients Aged 8-17 Years with Functional Dyspepsia Associated with Mucosal Eosinophilia.Paediatric drugs · 2024Trial
- Long-Term Outcomes After Therapeutic Induction in Patients with Functional Dyspepsia.Journal of clinical medicine · 2025Article
- Correlation of intratumoral mast cell quantity with psychosocial distress in patients with pancreatic cancer: the PancStress study.Scientific reports · 2024Article
- Article
- Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Does chronic urticaria affect quality of sleep and quality of life?Journal of public health research · 2024Article
- Review
- Global trends in research related to functional dyspepsia and anxiety or depression over the past two decades: a bibliometric analysis.Frontiers in neuroscience · 2023Article
- Research trends in the field of the gut-brain interaction: Functional dyspepsia in the spotlight - An integrated bibliometric and science mapping approach.Frontiers in neuroscience · 2023Review
- State of anxiety may be associated with exocrine pancreatic insufficiency in functional dyspepsia patients with pancreatic enzyme abnormalities.Journal of clinical biochemistry and nutrition · 2022Article
- Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake.Nutrients · 2022Article
- Immune Activation in Functional Dyspepsia: Bystander Becoming the Suspect.Frontiers in neuroscience · 2022Review
- Article
- Altered Vagal Signaling and Its Pathophysiological Roles in Functional Dyspepsia.Frontiers in neuroscience · 2022Review
- Update on the Role of Allergy in Pediatric Functional Abdominal Pain Disorders: A Clinical Perspective.Nutrients · 2021Review
- Endosonographic features in patients with non-alcoholic early chronic pancreatitis improved with treatment at one year follow up.Journal of clinical biochemistry and nutrition · 2021Article
- A cross-sectional study of nausea in functional abdominal pain: relation to mucosal mast cells and psychological functioning.BMC gastroenterology · 2020Article
- Sini San ameliorates duodenal mucosal barrier injury and low‑grade inflammation via the CRF pathway in a rat model of functional dyspepsia.International journal of molecular medicine · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with functional dyspepsia (FD) have increased risks for psychological dysfunction than healthy peoples. This study aimed to explore the roles of psychosocial factors and duodenal mast cells in the pathogenesis of FD. MATERIAL AND
methodsWe prospectively included 48 FD patients and 21 age- and sex-match healthy volunteers. There were 23 patients with postprandial distress syndrome (PDS) and 25 patients with epigastric pain syndrome (EPS). The Hospital Anxiety Depression Scale (HADS) was administered to evaluate their psychosocial status. Upper endoscopy was performed with biopsy of the mucosa from the bulb of duodenum. Mast cells counts and degranulation rates were identified by toluidine blue staining. The relationship among the scores of HADS-A (anxiety) and HADS-D (depression) and the mast cell counts and degranulation rates were analyzed.
resultsThe scores of HADS-A and HADS-D were significantly higher in PDS and EPS patients than the normal controls (P<0.05). The mast cell counts and degranulation rates in the duodenum were significantly increased in PDS and EPS patients than the controls (P<0.05). In either PDS or EPS patients, the HADS-A and HADS-D scores were positively correlated with the mast cell counts and degranulation rate.
conclusionFD patients had significantly higher risks for anxiety and depression, which may lead to FD through the increased mast cell counts and degranulation.
Indexed as
Identifiers
26221363PMC4509308W2398844461What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.