ArticleInternational journal of clinical and experimental medicine2015
Study on the association between IL-1β, IL-8 and IL-10 gene polymorphisms and risk of coronary artery disease.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Cytokine Gene Variants as Predisposing Factors for the Development and Progression of Coronary Artery Disease: A Systematic Review.Biomolecules · 2024Pooled it
- Association between interleukin-8 gene -251 A/T polymorphism and the risk of coronary artery disease: A meta-analysis.Medicine · 2019Pooled it
- Interleukin-8 Gene -251 A/T (rs4073) Polymorphism and Coronary Artery Disease Risk: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2019Pooled it
- Article
- Modulation of Vascular Smooth Muscle Cell Multiplication, Apoptosis, and Inflammatory Damage by miR-21 in Coronary Heart Disease.Computational and mathematical methods in medicine · 2021Article
- Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk.Current cardiology reports · 2019Review
- Protective effect of Xin-Ji-Er-Kang on cardiovascular remodeling in high salt-induced hypertensive mice.Experimental and therapeutic medicine · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to evaluate the role of genetic polymorphisms in IL-1β, IL-8 and IL-10 in the risk of coronary artery disease (CAD). We identified 325 patients with CAD and 342 control subjects without CAD between January 2013 and December 2014. Genotyping of IL-1β +3954 C/T, IL-1β -511 C/T, IL-8-251T/A, IL-10-1082A/G and IL-10-819C/T was performed in a 384-well plate format on the Sequenom MassARRAY platform (Sequenom, San Diego, USA). By Multivariate logistic regression analysis, the GG and AG+GG genotypes of IL-10-1082A/G were significantly associated with an increased risk of CAD. The ORs (95% CI) for GG and AG+GG genotypes were 2.12 (1.32-3.43) and 1.56 (1.14-2.14), respectively. Patients carrying the AG+GG genotype of IL-10-1082A/G was associated with an increased risk of CAD in those with hypertension, diabetes mellitus and smokers, and the ORs (95% CI) were 1.41 (0.93-2.14), 7.13 (2.28-23.56) and 2.12 (1.17-3.89), respectively. Our study found that IL-10-1082A/G polymorphism is associated with an increased risk of CAD, especially in hypertension, diabetes mellitus and smokers.
Indexed as
Identifiers
26221351PMC4509296W2409033322What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.