ArticleInternational journal of clinical and experimental medicine2015
Ocular syphilis: an alarming infectious eye disease.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Prognostic effect of HIV on visual acuity in ocular syphilis: a systematic review.Eye (London, England) · 2023Pooled it
- Acute syphilitic posterior placoid chorioretinitis.Eye (London, England) · 2025Article
- Leopard spot retinopathy represents the initial sign of rhegmatogenous retinal detachment in children: a report of two cases.BMC ophthalmology · 2024Article
- Article
- Clinical Features of Syphilis Patients with Ocular Symptoms as the Initial Manifestation.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Ocular syphilis in patients with human immunodeficiency virus/acquired immunodeficiency syndrome in the era of highly active antiretroviral therapy.Indian journal of ophthalmology · 2020Article
- The importance of proper and prompt treatment of ocular syphilis: a lesson from permanent vision loss in 52 eyes.Journal of the European Academy of Dermatology and Venereology : JEADV · 2020Article
- Syphilis Laboratory Guidelines: Performance Characteristics of Nontreponemal Antibody Tests.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Review
- Clinical Profile and Visual Outcomes of Ocular Syphilis: A Five-year Review in Hospital Universiti Sains, Malaysia.Cureus · 2019Article
- The ghost of the great imitator: prognostic factors for poor outcome in syphilitic uveitis.Journal of ophthalmic inflammation and infection · 2019Article
- Article
- Clinical manifestations and treatment outcomes of syphilitic uveitis in HIV-negative patients in China: A retrospective case study.Medicine · 2017Article
- Clinical Features and Treatments of Syphilitic Uveitis: A Systematic Review and Meta-Analysis.Journal of ophthalmology · 2017Review
- Three cases of ocular syphilis and the resurgence of the disease in Queensland.International medical case reports journal · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo describe the clinical manifestations and ancillary examination outcomes of ocular syphilis in Southeast China. MATERIALS AND
methodsThis is a retrospective, nonrandom case study. Demographic information, serum and cerebrospinal fluid (CSF) test results, and findings of fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), and spectral domain optical coherence tomography (SD-OCT) were analyzed.
resultsThe study examined 21 eyes of 13 patients (average age 50.3 ± 5.9 (range 37-61) years). HIV co-infection was found in one patient. The most common manifestation was chorioretinitis (52.4%). Disc hyperfluorescence (66.7%) and persistent dark spots (91.7%) were the most common findings on FFA and ICGA, respectively. The inner segment/outer segment junction (IS/OS) loss was the most frequent manifestation (86.7%). Among the six patients with confirmed neurosyphilis, the average CSF protein level was 528.8 ± 327.1 mg/L. Visual acuity (VA) was improved in 8 of 13 eyes (61.5%) after treatment.
conclusionsThe manifestations of ocular syphilis can mimic any eye disease. Chorioretinitis was the most common finding in this case series. "Leopard spots" was the characteristic manifestation on FFA. IS/OS loss was the most common finding in patients with posterior uveitis on SD-OCT. Lumbar puncture can contribute to the diagnosis of neurosyphilis. Treatment for ocular syphilis was effective in these patients.
Indexed as
Identifiers
26221328PMC4509273W937199538What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.