Evidence map›Paper›PMID 26221316›Full record

ArticleInternational journal of clinical and experimental medicine2015

Association between nonalcoholic fatty liver disease and carotid atherosclerosis: a meta-analysis.

Jia Cai, Shujun Zhang, Wenxiang Huang

Open access · greenAbstract read
In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. NAFLD and Extra-Hepatic Comorbidities: Current Evidence on a Multi-Organ Metabolic Syndrome.International journal of environmental research and public health · 2019
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jia CaiDepartment of Infectious Disease, The First Affiliated Hospital, Chongqing Medical University Chongqing 400016, China.
Shujun ZhangDepartment of Infectious Disease, The First Affiliated Hospital, Chongqing Medical University Chongqing 400016, China.
Wenxiang HuangDepartment of Infectious Disease, The First Affiliated Hospital, Chongqing Medical University Chongqing 400016, China.
The Affiliated Yongchuan Hospital of Chongqing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe carried out a meta-analysis about non-alcoholic fatty liver disease, carotid artery intima-media thickness and carotid artery plaque to explore the association between nonalcoholic fatty liver disease (NAFLD) and carotid atherosclerosis.

methodsWe searched for case-control studies about the relationship between NAFLD and carotid intima-media thick (IMT) published from 2004 to 2014 according to inclusion and exclusion criteria and extracted the relevant data. Statistical analysis was processed by RevMan 5.2 software.

results9 studies were involved totally, including 2446 subjects (925 patients and 1521 controls). We found that there was a significant heterogeneity between NAFLD and carotid IMT. By the random effects model we calculated and combined the mean value of carotid IMT. The mean difference was 0.16 mm with 95% confidence interval (0.11, 0.21). Studies showed that there was also heterogeneity between carotid artery plaque and NAFLD. By the random effects model the calculated and combined OR value was 3.73 with 95% confidence interval (2.42, 5.74). The publication bias of the included studies did not exist.

conclusionThe IMT in NAFLD patients increased 0.16 mm compared with the control group, and risk of carotid plaque was 3.73 times than that of the controls. It is necessary for NAFLD patients to carry out routine carotid ultrasound detection to predict the occurrence of carotid atherosclerosis and assess the risk of cardiovascular disease.

Indexed as

atherosclerosiscarotid arterycarotid intima-media thicknessmeta-analysisNon-alcoholic fatty liver disease

Identifiers

PMID26221316
PMCPMC4509261
OpenAlexW953712391

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.