Evidence map›Paper›PMID 26221304›Full record

ArticleInternational journal of clinical and experimental medicine2015

Relationship between gene mutations and protein expressions of PDGFR α and C-kit in gastrointestinal stromal tumors.

Jun-Yi He, H X Tong, Y Zhang, J Y Wang, Y B Shao, J Zhu, Wei-Qi Lu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jun-Yi HeDepartment of General Surgery, Zhongshan Hospital, Fudan University Shanghai 200032, China.
H X TongDepartment of General Surgery, Zhongshan Hospital, Fudan University Shanghai 200032, China.
Y ZhangDepartment of General Surgery, Zhongshan Hospital, Fudan University Shanghai 200032, China.
J Y WangDepartment of General Surgery, Zhongshan Hospital, Fudan University Shanghai 200032, China.
Y B ShaoDepartment of General Surgery, Zhongshan Hospital, Fudan University Shanghai 200032, China.
J ZhuDepartment of General Surgery, Zhongshan Hospital, Fudan University Shanghai 200032, China.
Wei-Qi LuDepartment of General Surgery, Zhongshan Hospital, Fudan University Shanghai 200032, China.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the relationship between gene mutations and protein expressions of PDGFR α and C-kit in gastrointestinal stromal tumors (GIST) and its significance in tumorigenesis.

methodsSingle strand conformation polymorphism-polymerase chain reaction (PCR-SSCP), immunohistochemistry and Western blot were used to detect the gene mutations in PDGFR α and C-kit and their protein expressions in 105 cases of GIST specimens.

resultsIn 105 cases of GIST, PDGFR α gene mutation was found in 12 cases (11.4%), which was common in the stomach- derived spindle cell GIST. C-kit gene mutation was found in 58 cases (55.2%), which was common in the small intestine. Mutations of PDGFR α is in 12 cases of GIST were stronger than the C-kit mutations in GIST, normal gastrointestinal tissues and schwannomas. No significant correlation was found between mutations and C-kit protein expression (P>0.05), while the protein expression of PDGFR α was significantly correlated with mutations (P<0.0001).

conclusionMutations of PDGFR α and C-kit plays an important role in part of GIST tumorigenesis. Mutation sites were related with original sites and histological types. Most protein expressions were closely related to their gene mutations in GIST.

Indexed as

C-kitgene mutationGISTPDGFR αSSCPWestern blot

Identifiers

PMID26221304
PMCPMC4509249
OpenAlexW1036451528

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.