ArticleInternational journal of clinical and experimental medicine2015
Effects of rosuvastatin on atrial nerve sprouting and electrical remodeling in rabbits with myocardial infarction.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Mechanisms Underlying Antiarrhythmic Properties of Cardioprotective Agents Impacting Inflammation and Oxidative Stress.International journal of molecular sciences · 2022Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study is to investigate the effect of rosuvastatin on atrial nerve sprouting and electrical remodeling after myocardial infarction (MI).
methodsRabbit MI model was established by anterior descending branch ligation. These models were divided into the sham (n = 9), MI model (n = 7), and rosuvastatin intervention (n = 8) groups. Immunohistochemistry was used to detect the autonomic atrial nerve distribution. Real-time PCR and Western blot analysis were performed to evaluate the mRNA and protein expression levels, respectively.
resultsOur results from immunohistochemistry showed that, compared with the sham group, the densities of tyrosine hydroxylase (TH)- and choline acetyltransferase (CHAT)-positive nerve fibers were significantly elevated in the MI model group. However, TH- and CHAT-positive nerve fibers were significantly decreased by rosuvastatin treatment, suggesting that rosuvastatin could reduce autonomic nerve sprouting in acute MI. Moreover, rosuvastatin decreased the mRNA and protein expression levels of TH in atrial tissues following MI. Compared with the sham group, the mRNA expression level of KCND3 was significantly down-regulated in the MI model group. And, this down-regulation was restored by rosuvastatin treatment. These results suggested that rosuvastatin could inhibit the electrical remodeling in atrium after acute MI.
conclusionAtrial nerve sprouting and electrical remodeling occur following MI, which could be suppressed by rosuvastatin treatment. Our findings provide insights into the understanding of the mechanism through which statins decrease the risk of atrium arrhythmia after MI.
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Identifiers
26221299PMC4509244W996215043What OpenQuestion holds
Registered trials
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