ArticleInternational journal of clinical and experimental medicine2015
Expression of AKAP95, Cx43, CyclinE1 and CyclinD1 in esophageal cancer and their association with the clinical and pathological parameters.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- High AKAP8L expression predicts poor prognosis in esophageal squamous cell carcinoma.Cancer cell international · 2022Article
- Upregulation of cyclin D1 can act as an independent prognostic marker for longer survival time in human nasopharyngeal carcinoma.Journal of clinical laboratory analysis · 2020Article
- Long noncoding RNA LINC01234 silencing exerts an anti-oncogenic effect in esophageal cancer cells through microRNA-193a-5p-mediated CCNE1 downregulation.Cellular oncology (Dordrecht, Netherlands) · 2020Article
- AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA.Cell chemical biology · 2019Article
- C6orf106 accelerates pancreatic cancer cell invasion and proliferation via activating ERK signaling pathway.Molecular and cellular biochemistry · 2019Article
- Upregulated LINC00565 Accelerates Ovarian Cancer Progression By Targeting GAS6.OncoTargets and therapy · 2019Article
- Telmisartan inhibits NSCLC A549 cell proliferation and migration by regulating the PI3K/AKT signaling pathway.Oncology letters · 2018Article
- CyclinD1 promotes lymph node metastasis by inducing lymphangiogenesis in human ovarian carcinoma.International journal of clinical and experimental pathology · 2018Article
- Epac1, PDE4, and PKC protein expression and their correlation with AKAP95 and Cx43 in esophagus cancer tissues.Thoracic cancer · 2017Article
- Knockdown of Immature Colon Carcinoma Transcript 1 Inhibits Proliferation and Promotes Apoptosis of Non-Small Cell Lung Cancer Cells.Technology in cancer research & treatment · 2017Article
- Egr-1 suppresses breast cancer cells proliferation by arresting cell cycle progression via down-regulating CyclinDs.International journal of clinical and experimental pathology · 2017Article
- Dynamic changes in protein interaction between AKAP95 and Cx43 during cell cycle progression of A549 cells.Scientific reports · 2016Article
- Downregulation of CREB Promotes Cell Proliferation by Mediating G1/S Phase Transition in Hodgkin Lymphoma.Oncology research · 2016Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate correlations among A-kinase anchor protein95 (AKAP95), Connexin43 (Cx43), CyclinE1 and CyclinD1 in esophageal squamous cell cancer tissues, and their relationship with clinical and pathological parameters.
methodsThe protein levels of AKAP95, Cx43, CyclinE1 and CyclinD1 in 54 cases of esophageal squamous cell cancer tissues were determined by immunohistochemistry.
resultsThe expression of AKAP95, CyclinE1 and CyclinD1 in esophageal squamous cell cancer tissues (53.70%, 88.89%, 72.22%, respectively) was significantly increased when compared to pericarcinoma tissues (20.00%, P < 0.05; 6.67%, P < 0.01; and 20.00%, P < 0.05; respectively). By contrast, Cx43 expression in esophageal squamous cell cancer tissues (22.22%) was lower than that in pericarcinoma tissues (60.00%, P < 0.05). The expression of AKAP95, Cx43, CyclinE1 and CyclinD1 in the tissues of esophageal squamous cell carcinoma was unrelated to lymph node metastasis and the degree of differentiation. The expression of Cx43, CyclinE1, CyclinD1 in the tissues of esophageal squamous cell carcinoma was significantly correlated with AKAP95, respectively (P < 0.05).
conclusionExpression levels of AKAP95, CyclinE1 and CyclinD1 were higher, and that of Cx43 lower in esophageal squamous cell carcinoma tissues as compared pericarcinoma tissues, which suggests their importance in the incidence and development of esophageal squamous cell carcinoma. The expression of Cx43, CyclinE1, CyclinD1 in the tissues of esophageal squamous cell carcinoma was correlated with AKAP95, respectively. The expression of AKAP95, Cx43, CyclinE1 and CyclinD1 in the tissues of esophageal squamous cell carcinoma was unrelated to the degree of differentiation and lymph node metastasis.
Indexed as
Identifiers
26221272PMC4509217W2418757643What OpenQuestion holds
Registered trials
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