Hepatopancreatic intoxication of lambda cyhalothrin insecticide on albino rats.

Manal Ea Elhalwagy, Sherif H Abd-Alrahman, A A Nahas, Reem M Ziada, Aziza H Mohamady

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Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed

–field-weighted citation impact, top 99% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

Toxicological impact of Thiamethoxam on adult male rats: Histopathological, biochemical, and oxidative DNA damage assessment.Toxicology reports · 2025
Article
Self-reported health effects of pesticides among cotton farmers from the Central-West region in Burkina Faso.Toxicology reports · 2023
Article
Lambda-cyhalothrin-induced pancreatic toxicity in adult albino rats.Scientific reports · 2023
Article
Effect of Lambdacyhalothrin on Locomotor Activity, Memory, Selected Biochemical Parameters, Tumor Necrosis Factor α, and Interleukin 1ß in a Mouse Model.International journal of environmental research and public health · 2020
Article
Combination of vortex assisted binary solvent microextraction and QuEChERS for the determination of prothiofos, oxadiargyl, and gamma-cyhalothrin in water and pineapple samples by gas chromatography mass spectrometry.Environmental monitoring and assessment · 2020
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Manal Ea ElhalwagyDepartment of Biochemistry, Faculty of Science for Girls, King Abdulaziz University P.O Box, 51459, Jeddah, 21453, KSA.

Sherif H Abd-AlrahmanBiochemistry Department, College of Science, King Saud University PO Box, 2455, Riyadh 11451, Saudi Arabia ; Department of Pesticide Residue and Environmental Pollution, Pesticide Central Laboratory, Agriculture Research Center Giza 12618, Egypt.

A A NahasDepartment of Mammalian Toxicology, Pesticide Central Laboratory, Agriculture Research Center Giza 12618, Egypt.

Reem M ZiadaDepartment of Mammalian Toxicology, Pesticide Central Laboratory, Agriculture Research Center Giza 12618, Egypt.

Aziza H MohamadyBioassay Department, Pesticide Central Laboratory, Agriculture Research Center Giza 12618, Egypt ; Chemistry Department, Faculty of Science, Hail University Hail, Kingdom of Saudi Arabia.

Central Laboratory For Agricultural Expert Systems · EGKing Abdulaziz University · SAKing Saud University · SAUniversity of Ha'il · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the known adverse effects of lambda cyhalothrin insecticide, little is known about its hepatopancreatic intoxication effects. The present study was carried out to elucidate sub-chronic effect of Karat 2.5% EC formulation of lambda cyhalothrin on male albino rats.

methodsTo explore the effects of exposure to lambda cyhalothrin on rats and its mechanism, low (1/40 of LD50, 5 mg/kg/day) and high dose (1/4 of LD50, 50 mg/kg/day) lambda cyhalothrin were applied to rats via drinking water for 3 months. Blood samples were collected monthly, and the animals were dissected for liver and pancreas's examination at the end of the experiment. Lambda cyhalothrin administration was associated with the elevation in lipid peroxidation marker, malondialdehyde (MDA), reduction in SH-protein a major marker for antioxidant, as well as basel paraoxonase (PON) in both treated groups throughout the experimental periods.

resultsIn addition, significant elevations in liver enzymes alanin amino transferase, (ALT), and aspartate amino transferase (AST), as well as plasma acetylcholinesterase (AChE) and glucose level. While, significant reduction in insulin level through the experimental periods. Results of histopathological and histochemical studies showed that lambda cyhalothrin exposure induces liver and pancreatic tissues damage and depletion in glycogen content was pronounced in liver of both treated groups.

conclusionsIn conclusion subchronic intoxication with lambda cyhalothrin formulation induced remarkable changes in the examined parameters.

Indexed as

liver enzymesoxidative stresspancreatic intoxicationPyrethroids

Identifiers

PMID26221269

PMCPMC4509214

OpenAlexW1005390832

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.