ArticleInternational journal of clinical and experimental medicine2015
Liver involvement of Langerhans' cell histiocytosis in children.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Structural and functional hepatic factors as prognostic indicators in children with Langerhans cell histiocytosis.Frontiers in oncology · 2026Article
- Beyond Hepatitis: A Rare Case of Multisystem Langerhans Cell Histiocytosis in a Child.Clinical case reports · 2025Article
- Cystic lesions and their mimics involving the intrahepatic bile ducts and peribiliary space: diagnosis, complications, and management.Abdominal radiology (New York) · 2025Review
- Clinical features and treatment outcomes of liver involvement in paediatric Langerhans cell histiocytosis.BMC pediatrics · 2024Article
- Article
- Current perspectives on the role of liver transplantation for Langerhans cell histiocytosis: A narrative review.World journal of gastroenterology · 2022Review
- Integrated imaging of systemic Langerhans cell histiocytosis in an infant.Radiology case reports · 2022Article
- Gut and liver involvement in pediatric hematolymphoid malignancies.World journal of gastrointestinal oncology · 2022Review
- Liver transplantation in a child with liver cirrhosis caused by langerhans cell histiocytosis: a case report.BMC pediatrics · 2022Article
- Hepatobiliary and Gastrointestinal Involvement in Langerhans Cell Histiocytosis-Spectrum of Three Cases.The Indian journal of radiology & imaging · 2021Article
- Multisystem Langerhans Cell Histiocytosis in an infant.Radiology case reports · 2021Article
- Hepatic Langerhans cell histiocytosis: A review.World journal of clinical oncology · 2021Review
- Article
- Isolated hypothalamic-pituitary langerhans' cell histiocytosis in female adult: A case report.Medicine · 2019Article
- Langerhans cell histiocytosis in children - a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment.Postepy dermatologii i alergologii · 2018Review
- Abdominal manifestations of histiocytic disorders in adults: imaging perspective.The British journal of radiology · 2016Review
- 18F-Fluorodeoxyglucose PET/CT in Langerhans cell histiocytosis: spectrum of manifestations.Japanese journal of radiology · 2016Review
- Bile Duct Targeting or Preservation: Contrasting Liver Histology in Langerhans Cell Histiocytosis and Disseminated Juvenile Xanthogranuloma.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology SocietyReview
- Imaging of Histiocytosis in the Era of Genomic Medicine.Radiographics : a review publication of the Radiological Society of North America, IncReview
- Seborrheic-like dermatitis and liver dysfunction in an infant: signs of Langerhans cell histiocytosis.Anais brasileiros de dermatologiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLiver involvement is relatively frequent in children with Langerhans cell histiocytosis (LCH). Its features remain poorly defined.
methodsA retrospective study was carried out on 14 hepatic LCH children in our hospital. The Clinicopathological and radiological features of this disease was discussed.
resultsThe rate of liver involvement in children LCH patients is 51.9%. Majority of the patients were disseminated cases. Hepatomegaly was clinically confirmed in 11 cases (78.6%). Liver function dysfunction was seen in nine (64.3%) children. The association of multi-modal imaging significantly yielded more diagnostic information. There are some imaging characteristics of this disease, CT and MRI could help to assess the staging, extent of the hepatic lesions. We found that liver involvement had a significant impact on survival. Patients treated with systemic chemotherapy earlier from time of diagnosis had a relatively better outcome.
conclusionsThe rate of liver involvement in children LCH patients maybe much higher than that of expected. We suggest that clinical and biological liver evaluation and abdominal imaging must be performed regularly onwards to screen every LCH children patient from the time of the initial diagnosis. Patient should be treated with systemic chemotherapy earlier.
Indexed as
Identifiers
26221247PMC4509192What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.