ArticleInternational journal of clinical and experimental medicine2015
RELMα can cause contraction of rat aortic smooth muscle cells.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Trifolin inhibits the calcium-driven contraction pathway in vascular smooth muscle.Frontiers in pharmacology · 2025Article
- Mechanism of Hypoxia-Mediated Smooth Muscle Cell Proliferation Leading to Vascular Remodeling.BioMed research international · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aims to observe the contraction role of RELMα in rat aortic smooth muscle cells and explore its mechanism.
methodsRat aortas smooth muscle cells were cultivated using tissue explants method. They were divided into 5 groups. A: Control group; B: 1×10(-7) mol/L ANGII group; C: 1×10(-8) mol/L RELMα group; D: 2×10(-8) mol/L RELMα group; E: 4×10(-8) mol/L RELMα group. The thoracic aortic tension signal of rats was recorded by Powerlab system. The expression levels of CaM and MLCK were detected by western blotting and RT-PCR methods.
resultsTension changes of rat thoracic aorta vascular ring in group C, D and E (72±2.98%, 76.65±2.73%, 85.07±3.06% respectively) were higher than that of group A and B (6.35±0.75%, 61.47±4.47%) with dose-dependent (P<0.01). The expression levels of CaM and MLCK in group C were higher than that of group A and B while were lower than that of group D and E (P<0.05). The expression levels of CaM and MLCK in group E were the highest among the groups (P<0.05).
conclusionsRELMα can cause contraction of rat aortic smooth muscle cells, its mechanism may be via Ca(2+)-CaM-MLCK pathway.
Indexed as
Identifiers
26221238PMC4509183What OpenQuestion holds
Registered trials
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