ArticleInternational journal of clinical and experimental medicine2015
Qian Five Rhinoceros Gindeng (QFRG) protects against development of immune thrombocytopenia via miR-181a inhibition of TLR-4 expression.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- MicroRNAs as potential architects of immune dysregulation and megakaryocytic failure in immune thrombocytopenia.British journal of haematology · 2026Review
- Integrating "Yang transforming Qi and Yin constituting the body" with immune regulation: an evidence synthesis of multidimensional traditional chinese medicine therapy for immune thrombocytopenia.Chinese medicine · 2026Review
- Integrating network pharmacology and experimental validation to explore the mechanism of Yiqi Ziyin in treating immune thrombocytopenia.Scientific reports · 2025Article
- Sensitivity of miRNA-181a, miRNA-23b and miRNA-16 in the Late-Onset Neonatal Sepsis: A Diagnostic Study.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2024Article
- Article
- Clinical significance of miR-181a in patients with neonatal sepsis and its regulatory role in the lipopolysaccharide-induced inflammatory response.Experimental and therapeutic medicine · 2020Article
- Elucidation of the Mechanisms and Molecular Targets of Yiqi Shexue Formula for Treatment of Primary Immune Thrombocytopenia Based on Network Pharmacology.Frontiers in pharmacology · 2019Article
- MicroRNA-181b negatively regulates the proliferation of human epidermal keratinocytes in psoriasis through targeting TLR4.Journal of cellular and molecular medicine · 2017Article
- The Extensive Regulation of MicroRNA in Immune Thrombocytopenia.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisReview
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTraditional Chinese medicine (TCM) has been considered to be effective auxiliary strategy for the treatment of hemocytopenia including immune thrombocytopenia. However, the molecular mechanism is still not understood.
methodsIn present study, Qian Five Rhinoceros Gindeng (QFRG) mainly containing buffalo horn, rehmannia root, radix rubia, trogopterus dung and radix salviae miltiorrhizae administrated to thrombocytopenia mice induced by injection of MWReg30. MicroRNAs (miRNAs), Toll Like Receptors (TLRs) and cytokines were assayed in monocytes separated from mice peripheral blood. The relationship between miRNAs and TLRs was investigated in Mouse leukaemic monocyte macrophage cell line RAW264.7.
resultsThe mice with administration of QFRG had a significant increase in platelet count, and miR-181a of monocytes was markedly up-regulated in QFRG treated group. QFRG also decreased the levels of TLR4, IL-6 and TNF-α. In addition, miR-181a inhibitor reversed the effects of QFRG on platelet count, TLR4 and cytokines. Overexpression of miR-181a in lipopolysaccharide-induced showed a decrease of TLR4, IL-6 and TNF-α level.
conclusionsQFRG protects against development of immune thrombocytopenia via miR-181a inhibition of TLR-4 expression.
Indexed as
Identifiers
26221235PMC4509180W1043380543What OpenQuestion holds
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