ArticleInternational journal of clinical and experimental medicine2015
Platelet mitochondrial dysfunction of DM rats and DM patients.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Platelet Apoptosis in Patients with Coronary Artery Disease Before and After CABG.International journal of molecular sciences · 2026Article
- Platelet mitochondria dysfunction in diabetes mellitus: mechanisms and therapeutic implications.Frontiers in pharmacology · 2026Review
- Altered branched chain ketoacids underlie shared metabolic phenotypes in type 1 diabetes and maple syrup urine disease.Communications medicine · 2025Article
- Understanding the Role of Oxidative Stress in Platelet Alterations and Thrombosis Risk among Frail Older Adults.Biomedicines · 2024Review
- Investigation of Platelet Apoptosis in Patients after Surgical Myocardial Revascularization.Biomedicines · 2023Article
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- Functional role and molecular mechanisms underlying prohibitin 2 in platelet mitophagy and activation.Molecular medicine reports · 2021Article
- Investigating the effect of age on platelet ultrastructure using transmission electron microscopy.International wound journal · 2019Article
- Pinocembrin Attenuates Mitochondrial Dysfunction in Human Neuroblastoma SH-SY5Y Cells Exposed to Methylglyoxal: Role for the Erk1/2-Nrf2 Signaling Pathway.Neurochemical research · 2017Article
- Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is known that cardiovascular complications plays important roles in the development of diabetes mellitus (DM) and platelet dysfunction is one of the key reasons which led to microangiopathy. This study was designed to investigate the mitochondria function changes of platelet in DM rats and DM patients. The results showed that the platelets viability, platelet adenosine triphosphate (ATP) content and platelet mitochondrial ATP content of DM rats were lower than that of normal rats; when incubated in vitro for 24 h, platelet number and mitochondrial membrane potential (MMP) of DM rats were lower than that of normal rats, reactive oxygen species (ROS) was higher than that of normal rats. For DM patients, their platelet number and ROS were higher and MMP was lower than those of normal people; when incubated in vitro for 24 h, platelet viability of DM patients was lower than that of normal people. Platelet ultra-microstructures of DM rats and DM patients were abnormal. These results suggested that platelet mitochondrial function of both DM rats and DM patients was impaired when compared to normal rats and normal people, respectively. Platelets may be applied as a biomarker to observe the mitochondrial changes during DM.
Indexed as
Identifiers
26221230PMC4509175W2416156415What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.