ArticleInternational journal of clinical and experimental medicine2015
Effects and safety of magnesium sulfate on propofol-induced injection pain, a meta-analysis of randomized controlled trials.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Preventive effect of a vapocoolant spray on propofol-induced pain: a prospective, double-blind, randomized study.Journal of anesthesia · 2017Trial
- Trial
- Perioperative Magnesium for Postoperative Analgesia: An Umbrella Review of Systematic Reviews and Updated Meta-Analysis of Randomized Controlled Trials.Journal of personalized medicine · 2021Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPropofol is the most widely used drug in the induction of general anesthesia, however its disadvantages of injection pain has always been a problem for clinical anesthetists. Many strategies have been proposed and magnesium sulfate is one of them. This is the first meta-analysis studies evaluating effects of magnesium sulfate pretreatment for preventing propofol-induced injection pain.
methodsWe searched MEDLINE, EMBASE, Google scholar and the Cochrane Database of Systematic Review databases for randomized controlled trials (RCTs) that evaluated the prophylactic effect of magnesium sulfate on propofol injection pain. Meta-analyses were performed using RevMan 5.3 software.
resultsFive RCTs involving 545 participants were included. Magnesium sulfate allows more patients experiencing no pain or mild pain during propofol injection ([RR] 2.70, 95% [CI] 1.10-6.64, P=0.03, 2.12,95% CI 1.46-3.08, P < 0.0001, respectively). And the number of patients with severe pain (RR 0.12, 95% CI 0.06-0.25, P < 0.00001) on injecting propofol were significantly decreased. However, no statistical significance was found between magnesium sulfate group and placebo group in moderate pain (RR 0.22, 95% CI 0.05-0.97, P=0.05).
conclusionOur meta-analysis suggested that pretreatment with magnesium sulfate intravenously before injecting propofol allow more patients to experiencing no pain during propofol injection and can reduce the intensity of injection pain effectively without causing any adverse effect.
Indexed as
Identifiers
26221219PMC4509164What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.