ArticleIranian journal of reproductive medicine2015
Oxytocin can decrease germ cells apoptotic index in testis under acute ischemia reperfusion in a rat model.
Article in Iranian journal of reproductive medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Increasing the fertility of Sapudi sheep semen at 5°C storage temperature with the addition of oxytocin in a diluent of skim milk, egg yolk, and citrate.Open veterinary journal · 2025Article
- Oxytocin Protects PC12 Cells Against β-Amyloid-Induced Cell Injury.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Oxytocin ameliorates lipopolysaccharide-induced acute orchitis model: interplay of oxidative stress and inflammatory pathways.Frontiers in pharmacology · 2024Article
- The role of taurine in male reproduction: Physiology, pathology and toxicology.Frontiers in endocrinology · 2023Review
- The Importance of Experimental Investigation of the Peripheral Oxytocin System.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Determination of histological, immunohistochemical and biochemical effects of acute and chronic grayanotoxin III administration in different doses in rats.Environmental science and pollution research international · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledIschemia reperfusion (IR) is the main pathology of torsion of testis and it is a common urologic emergency. There is some evidence that shows oxytocin (OT) plays role in ischemia reperfusion.
objectiveTo evaluate this hypothesis that OT can decrease germ cell apoptotic index in testis under acute ischemia reperfusion in a rat model. MATERIALS AND
methods20 adult rats were randomly divided into four groups: Control, IR, OT and IR+ OT (OTA). Testicular ischemia was achieved by 720° torsion of the left testis for 2 hr. Then, torsion was removed and reperfusion was performed. Immediately after induction of reperfusion 0.03 µg/kg OT were administered intraperitoneally to the IR+ OT. Three hours after surgery left testis was removed and evaluations were made by Johnson's score, ELISA, immunohistochemistry and histomorphometry for study of maturity of spermatogenesis, endocrine profiles, apoptosis and quantitative studies, respectively.
resultsThe results showed in addition tissue edema and congestion, a significant reduced in Johnson's score were detected in IR group in comparison with controls (p=0.01), and apoptotic index increased significantly (p=0.001). Administration of OT in OT+IR group, increased Johnson's score but it was not statistically significant. Germinal epithelium thickness was increased significantly (p=0.03), although apoptotic index decreased significantly in comparison with the IR group (p=0.04). However there was not significant difference in serum levels of testosterone, FSH and LH in none of groups (p=0.07).
conclusionThese results suggested that OT can decrease apoptotic index and improves complication of acute ischemic reperfusion in testis in a rat model.
Indexed as
Identifiers
26221127PMC4515235W1572249316What OpenQuestion holds
Registered trials
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