ReviewIranian journal of reproductive medicine2015
The imbalance in expression of angiogenic and anti-angiogenic factors as candidate predictive biomarker in preeclampsia.
Review in Iranian journal of reproductive medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Trophoblast Function in Preeclampsia: Decoding the Mechanistic Roles of Coding and Non-Coding Genes.International journal of molecular sciences · 2025Review
- Endoplasmic reticulum stress: an emerging therapeutic target for preeclampsia†.Biology of reproduction · 2025Review
- A Review of the Diagnosis, Risk Factors, and Role of Angiogenetic Factors in Hypertensive Disorders of Pregnancy.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Review
- Inhibition of FLT1 Attenuates Neurodevelopmental Abnormalities and Cognitive Impairment in Offspring Caused by Maternal Prenatal Stress.Applied biochemistry and biotechnology · 2024Article
- Model for Early Prediction of Preeclampsia: A Nested Case Controlled Study in Indian Women.Journal of obstetrics and gynaecology of India · 2022Article
- Role of Vascular Endothelial Growth Factor (VEGF) in Human Embryo Implantation: Clinical Implications.Biomolecules · 2021Review
- Dysregulated BMP2 in the Placenta May Contribute to Early-Onset Preeclampsia by Regulating Human Trophoblast Expression of Extracellular Matrix and Adhesion Molecules.Frontiers in cell and developmental biology · 2021Article
- Serum From Preeclamptic Women Triggers Endoplasmic Reticulum Stress Pathway and Expression of Angiogenic Factors in Trophoblast Cells.Frontiers in physiology · 2021Article
- Evaluation of Placental VEGFA mRNA Expression in Preeclampsia: A Case Control Study.Journal of obstetrics and gynaecology of India · 2019Article
- Obesity "complements" preeclampsia.Physiological genomics · 2019Review
- Transcriptome analysis of the effect of pyrroloquinoline quinone disodium (PQQ·NaJournal of animal science and biotechnology · 2019Article
- Disruption in the Regulation of Immune Responses in the Placental Subtype of Preeclampsia.Frontiers in immunology · 2018Review
- Cadmium inhibits placental trophoblast cell migration via miRNA regulation of the transforming growth factor beta (TGF-β) pathway.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2017Article
- Hypoxia downregulates the angiogenesis in human placenta via Notch1 signaling pathway.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017Article
- miRNAs as common regulators of the transforming growth factor (TGF)-β pathway in the preeclamptic placenta and cadmium-treated trophoblasts: Links between the environment, the epigenome and preeclampsia.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preeclampsia is an important pregnancy disorder with serious maternal and fetal complications which its etiology has not been completely understood yet. Early diagnosis and management of disease could reduce its potential side effects. The vascular endothelial growth factor (VEGF) family including VEGF-A is the most potent endothelial growth factor which induces angiogenesis and endothelial cell proliferation and has basic role in vasculogenesis. VEGF and its tyrosine kinase receptors (Flt1 and KDR) are major factors for fetal and placental angiogenic development. Finding mechanisms involved in expression of angiogenic factors may lead to new prognostic and therapeutic points in management of preeclampsia. Recent researches, has shown capability of some anti-angiogenic factors as potential candidate to be used as early predictors for preeclampsia. Soluble fms-like tyrosin kinase-1 (sFlt1) is a truncated splice variant of the membrane-bound VEGF receptor Flt1, that is produced by the placenta and it can bind to angiogenic growth factors and neutraliz, their effects. It is also observed that the ratio of sFlt1 to placental growth factor is valuable as prognostic marker. In this review, VEGF family member's role in angiogenesis is evaluated as biomarkers to be used for prediction of preeclampsia.
Indexed as
Identifiers
26221124PMC4515231W2237478084What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.