ArticleTsinghua science and technology2015
A New Hidden Markov Model for Protein Quality Assessment Using Compatibility Between Protein Sequence and Structure.
Article in Tsinghua science and technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- MUfoldQA_G: High-accuracy protein model QA via retraining and transformation.Computational and structural biotechnology journal · 2021Article
- Two New Heuristic Methods for Protein Model Quality Assessment.IEEE/ACM transactions on computational biology and bioinformaticsArticle
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Authors and funding
4 authors.
Funding
Abstract
Protein structure Quality Assessment (QA) is an essential component in protein structure prediction and analysis. The relationship between protein sequence and structure often serves as a basis for protein structure QA. In this work, we developed a new Hidden Markov Model (HMM) to assess the compatibility of protein sequence and structure for capturing their complex relationship. More specifically, the emission of the HMM consists of protein local structures in angular space, secondary structures, and sequence profiles. This model has two capabilities: (1) encoding local structure of each position by jointly considering sequence and structure information, and (2) assigning a global score to estimate the overall quality of a predicted structure, as well as local scores to assess the quality of specific regions of a structure, which provides useful guidance for targeted structure refinement. We compared the HMM model to state-of-art single structure quality assessment methods OPUSCA, DFIRE, GOAP, and RW in protein structure selection. Computational results showed our new score HMM.Z can achieve better overall selection performance on the benchmark datasets.
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