Evidence map›Paper›PMID 26221050›Full record

ReviewSchizophrenia bulletin2016

Interventions to Address Medical Conditions and Health-Risk Behaviors Among Persons With Serious Mental Illness: A Comprehensive Review.

Emma E McGinty, Julia Baller, Susan T Azrin, Denise Juliano-Bult, Gail L Daumit

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 4 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 4 syntheses or guidelines pooled it, 134 citations in OpenAlex.

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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Emma E McGintyDepartments of Health Policy and Management and Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; bmcginty@jhu.edu.
Julia BallerDepartments of Health Policy and Management and Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD;
Susan T AzrinNational Institute of Mental Health, Bethesda, MD;
Denise Juliano-BultNational Institute of Mental Health, Bethesda, MD;
Gail L DaumitDivision of General Internal Medicine, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD.
Johns Hopkins University · USNational Institute of Mental Health · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Developing and Translating Interventions to Decrease Mortality Disparities in SMIK24MH093763 · NIMH · JOHNS HOPKINS UNIVERSITY · PI DAUMIT, GAIL L. · 2012 to 2016
$830k
Improving Evidence-based Behavioral, Somatic and Social Service Delivery for SMIK01MH106631 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MCGINTY, EMMA ELIZABETH · 2015 to 2018
$711k
NCATS NIH HHS UL1 TR001079NIMH NIH HHS K01 MH106631NIMH NIH HHS K24 MH093763
6 · The paper itself

Abstract

People with serious mental illness (SMI) have mortality rates 2 to 3 times higher than the overall US population, largely due to cardiovascular disease. The prevalence of cardiovascular risk factors such as obesity and diabetes mellitus and other conditions, such as HIV/AIDS, is heightened in this group. Based on the recommendations of a National Institute of Mental Health stakeholder meeting, we conducted a comprehensive review examining the strength of the evidence surrounding interventions to address major medical conditions and health-risk behaviors among persons with SMI. Peer-reviewed studies were identified using 4 major research databases. Randomized controlled trials and observational studies testing interventions to address medical conditions and risk behaviors among persons with schizophrenia and bipolar disorder between January 2000 and June 2014 were included. Information was abstracted from each study by 2 trained reviewers, who also rated study quality using a standard tool. Following individual study review, the quality of the evidence (high, medium, low) and the effectiveness of various interventions were synthesized. 108 studies were included. The majority of studies examined interventions to address overweight/obesity (n = 80). The strength of the evidence was high for 4 interventions: metformin and behavioral interventions had beneficial effects on weight loss; and bupropion and varenicline reduced tobacco smoking. The strength of the evidence was low for most other interventions reviewed. Future studies should test long-term interventions to cardiovascular risk factors and health-risk behaviors. In addition, future research should study implementation strategies to effectively translate efficacious interventions into real-world settings.

Indexed as

Risk Reduction BehaviorBehavior TherapyBipolar DisorderBupropionCardiovascular DiseasesDiabetes MellitusDopamine Uptake InhibitorsHealth BehaviorHIV InfectionsHumansHyperlipidemiasHypertensionHypoglycemic AgentsMetforminMotor ActivityNicotinic AgonistsBupropionDopamine Uptake InhibitorsHypoglycemic AgentsMetforminNicotinic AgonistsVareniclineinterventionmedicalobesityschizophreniasomatictobacco

Identifiers

PMID26221050
PMCPMC4681556
OpenAlexW2258694815

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.