ArticleWorld journal of microbiology & biotechnology2015
An endophyte of Picrorhiza kurroa Royle ex. Benth, producing menthol, phenylethyl alcohol and 3-hydroxypropionic acid, and other volatile organic compounds.
Article in World journal of microbiology & biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 26 citations in OpenAlex.
- Trypanocidal Activity of Crude Extracts fromJournal of fungi (Basel, Switzerland) · 2026Article
- The power of the smallest: The inhibitory activity of microbial volatile organic compounds against phytopathogens.Frontiers in microbiology · 2022Review
- Bioprospecting of endophytic microorganisms for bioactive compounds of therapeutic importance.Archives of microbiology · 2021Review
- Diffusible Compounds Produced byAntibiotics (Basel, Switzerland) · 2021Article
- Identification of VOCs in essential oils extracted using ultrasound- and microwave-assisted methods from sweet cherry flower.Scientific reports · 2021Article
- Low Molecular Weight Volatile Organic Compounds Indicate Grazing by the Marine RotiferMetabolites · 2020Article
- An EndophyticAntibiotics (Basel, Switzerland) · 2019Article
- Antifungal Activities of Volatile Secondary Metabolites of FourJournal of fungi (Basel, Switzerland) · 2018Article
- Diversity of cultivable fungal endophytes in Paullinia cupana (Mart.) Ducke and bioactivity of their secondary metabolites.PloS one · 2018Article
- An Insight into the Secondary Metabolism of Muscodor yucatanensis: Small-Molecule Epigenetic Modifiers Induce Expression of Secondary Metabolism-Related Genes and Production of New Metabolites in the Endophyte.Microbial ecology · 2017Article
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
An endophytic fungus, PR4 was found in nature associated with the rhizome of Picrorhiza kurroa, a high altitude medicinal plant of Kashmir Himalayas. The fungus was found to inhibit the growth of several phyto-pathogens by virtue of its volatile organic compounds (VOCs). Molecular phylogeny, based on its ITS1-5.8S-ITS2 ribosomal gene sequence, revealed the identity of the fungus as Phomopsis/Diaporthe sp. This endophyte was found to produce a unique array of VOCs, particularly, menthol, phenylethyl alcohol, (+)-isomenthol, β-phellandrene, β-bisabolene, limonene, 3-pentanone and 1-pentanol. The purification of compounds from the culture broth of PR4 led to the isolation of 3-hydroxypropionic acid (3-HPA) as a major metabolite. This is the first report of a fungal culture producing a combination of biologically and industrially important metabolites—menthol, phenylethyl alcohol, and 3-HPA. The investigation into the monoterpene biosynthetic pathway of PR4 led to the partial characterization of isopiperitenone reductase (ipr) gene, which seems to be significantly distinct from the plant homologue. The biosynthesis of plant-like-metabolites, such as menthol, is of significant academic and industrial significance. This study indicates that PR4 is a potential candidate for upscaling of menthol, phenylethyl alcohol, and 3-HPA, as well as for understanding the menthol/monoterpene biosynthetic pathway in fungi.
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