ArticleIranian biomedical journal2015
Prevalence of Class 1 Integrons and Extended Spectrum Beta Lactamases among Multi-Drug Resistant Escherichia coli Isolates from North of Iran.
Article in Iranian biomedical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 35 citations in OpenAlex.
- Ampicillin- and Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Detection of Integrons inInternational journal of microbiology · 2025Article
- Characterization of integrons, extended spectrum beta lactamases and genetic diversity among uropathogenicIranian journal of microbiology · 2023Article
- Genetic characterization of third- or fourth-generation cephalosporin-resistant avian pathogenicFrontiers in veterinary science · 2022Article
- Epidemiology and antimicrobial susceptibility profiles of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae and Escherichiacoli in China.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- Antimicrobial Effects of Chemically Functionalized and/or Photo-Heated Nanoparticles.Materials (Basel, Switzerland) · 2019Article
- Antimicrobial resistance genes in Salmonella and Escherichia coli isolates from chicken droppings in Nairobi, Kenya.BMC research notes · 2019Article
- Detection of Antimicrobial Susceptibility and Integrons Among Extended-spectrum β-lactamase Producing UropathogenicOman medical journal · 2018Article
- Gene cassettes of class I integron-associated with antimicrobial resistance in isolates ofIranian journal of microbiology · 2018Article
- Review
- EXTENDED-SPECTRUM BETA-LACTAMASE PRODUCING GRAM NEGATIVE BACTERIA IN IRAN: A REVIEW.African journal of infectious diseases · 2017Article
- The antimicrobial activity of nanoparticles: present situation and prospects for the future.International journal of nanomedicine · 2017Review
- Occurrences and Characterization of Antibiotic-Resistant Bacteria and Genetic Determinants of Hospital Wastewater in a Tropical Country.Antimicrobial agents and chemotherapy · 2016Article
- Antimicrobial resistance and integron gene cassette arrays in commensal Escherichia coli from human and animal sources in IRI.Gut pathogens · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtended spectrum beta lactamases (ESBLs) are an important cause of transferable multidrug resistance (MDR) in gram-negative bacteria. The most described ESBL genes are generally found within integron-like structures as mobile genetic elements. The aim of this study was to identify the accompanying of class 1 integrons and ESBLs in the MDR E. coli isolates.
methodsSusceptibility to antimicrobial agents was determined for 33 E. coli strains by the disk diffusion method. Double-disk synergy test was applied for screening ESBL. To identify the strains carrying integrons, the conserved regions of integron-encoded integrase gene intI1 were amplified. For detection of gene cassettes, 5'CS and 3'CS primers were used.
resultsAll E. coli isolates were identified as multi-drug resistant. More than 50% of the isolates were resistant to tetracycline, cephalothin, cefuroxime, amoxicillin-clavulanic acid, and third generation cephalosporines. Nearly all of the isolates displayed sensitivity to piperacillin. There was a significant correlation between production of ESBL and resistance to all antibiotics except for ciprofloxacin and piperacillin (P value less than 0.01). Thirty two MDR strains (97%) included class 1 integron, and some isolates that included integrons were similar in the size of gene cassettes. The isolates were different in the resistance profiles; however, some others had similar resistance profiles. Of eight ESBL positive isolates, seven (87.5%) carried class 1 integrons.
conclusionClass 1 integrons were frequent in MDR and also ESBL-producing E. coli isolates. High prevalence of class 1 integrons confirms that integron-mediated antimicrobial gene cassettes are important in E. coli resistance profile.
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