ArticlePsychopharmacology2015
Genetic influences on delay discounting in smokers: examination of a priori candidates and exploration of dopamine-related haplotypes.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- The Genoeconomics of Impulsive Intertemporal Choice: A Critical Review.Journal of the experimental analysis of behavior · 2026Review
- Balancing Risk and Reward: Dopamine's Central Role in Economic Decision-Making.Brain sciences · 2025Review
- The Impact of Adverse Childhood Experiences on the Development of Adolescent Risk-Taking: The Mediating Effect of Self-Control and Moderating Effect of Genetic Variations.Journal of youth and adolescence · 2025Article
- Genetic Propensity for Delay Discounting and Educational Attainment in Adults Are Associated With Delay Discounting in Preadolescents: Findings From the Adolescent Brain Cognitive Development Study.Genes, brain, and behavior · 2025Article
- Longitudinal characterization of impulsivity phenotypes boosts signal for genomic correlates and heritability.Molecular psychiatry · 2025Article
- Correspondence between the alcohol-P3 event-related potential and alcohol reward phenotypes among young adults.Alcohol, clinical & experimental research · 2024Article
- Individual Differences in Intertemporal Choice.Frontiers in psychology · 2021Review
- The neurobiology of impulsivity and substance use disorders: implications for treatment.Annals of the New York Academy of Sciences · 2019Review
- Linking Delay Discounting and Substance Use Disorders: Genotypes and Phenotypes.Perspectives on behavior science · 2019Article
- Early life adversity and increased delay discounting: Findings from the Family Health Patterns project.Experimental and clinical psychopharmacology · 2019Article
- Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach.Experimental and clinical psychopharmacology · 2019Article
- Neural underpinnings of maladaptive decision-making in addictions.Pharmacology, biochemistry, and behavior · 2018Review
- Attention-Deficit/Hyperactivity Disorder and Monetary Delay Discounting: A Meta-Analysis of Case-Control Studies.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
- The Behavioral Economics and Neuroeconomics of Alcohol Use Disorders.Alcoholism, clinical and experimental research · 2016Review
- Impulsive delayed reward discounting as a genetically-influenced target for drug abuse prevention: a critical evaluation.Frontiers in psychology · 2015Review
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 2 countries.
Funding
Abstract
rationaleDelay discounting is a behavioral economic index of impulsivity that reflects a person's relative preference for small immediate rewards versus larger delayed rewards. Elevated delay discounting is robustly linked to addictive disorders and has been increasingly investigated as a viable endophenotype for genetic influences on addiction.
objectiveThe aim of this study is to examine associations between delay discounting and two a priori loci, rs4680 in COMT and rs1800497 in ANKK1, and three exploratory haplotypes proximal to rs1800497 in a sample of daily smokers.
methodsParticipants were 713 (60.2 % male) daily smokers of European ancestry who completed a delay discounting assessment and provided a DNA sample.
resultsSignificant associations were detected between greater discounting of medium magnitude rewards (~$55) and the G allele of rs4680, as well as the T allele of rs1800497. Exploratory haplotype analyses identified two haplotypes (rs1160467/rs1800497; rs6277/rs1079597) significantly associated with delay discounting rates. However, the rs1160467/rs1800497 haplotype associations appeared to be entirely attributable to variation in rs1800497, suggesting that the association of rs1800497 with discounting is best understood at the individual SNP level. Similarly, the rs6277/rs1079597 haplotype findings suggested that the association was specific to rs1079597.
conclusionsThis study provides further evidence that rs4680 and rs1800497 genotypes are significantly associated with delay discounting preferences and does so among smokers for the first time. The study also provides evidence of specificity for the rs1800497 association and identifies a novel locus, rs1079597, as a genetic contributor to higher delay discounting rates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.