Evidence map›Paper›PMID 26220610›Full record

ArticlePsychopharmacology2015

A novel 2- and 3-choice touchscreen-based continuous trial-unique nonmatching-to-location task (cTUNL) sensitive to functional differences between dentate gyrus and CA3 subregions of the hippocampus.

C A Oomen, M Hvoslef-Eide, D Kofink, F Preusser, A C Mar, L M Saksida, T J Bussey

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Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

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10citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

C A Oomen *Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
M Hvoslef-Eide *Department of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
D KofinkDepartment of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
F PreusserDepartment of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
A C MarDepartment of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
L M SaksidaDepartment of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.
T J BusseyDepartment of Psychology, University of Cambridge, Cambridge, CB2 3EB, UK.

Funding

Medical Research Council MC_G1000734Wellcome Trust 089703
6 · The paper itself

Abstract

rationaleThe touchscreen continuous trial-unique non-matching-to-location task (cTUNL) has been developed to optimise a battery of tasks under NEWMEDS (Novel Methods leading to New Medication in Depression and Schizophrenia, http://www.newmeds-europe.com ). It offers novel task features of both a practical and a theoretical nature compared to existing touchscreen tasks for spatial working memory.

objectivesThe objective of this study was to determine whether the cTUNL task is sufficiently sensitive to differentiate between dentate gyrus (DG) and CA3 hippocampal subregion contributions to performance.

methodsThe effect of DG and CA3 dysfunction on memory for locations in the cTUNL task was tested. Rats were assessed on versions of the task-two-choice and three-choice-that differed in memory load. Performance was challenged using manipulations of delay and the spatial separation between target and sample locations.

resultsDysfunction of the DG disrupts performance across both delay and spatial separations in two-choice cTUNL when the delay is variable and unpredictable. Increasing the working memory load (three stimuli) increases sensitivity to DG dysfunction, with deficits apparent at fixed, short delays. In contrast, CA3 dysfunction did not disrupt performance.

conclusionAcquisition of cTUNL was rapid, and the task was sensitive to manipulations of delays and separations. A three-choice version of the task was found to be viable. Finally, both the two- and three-choice versions of the task were able to differentiate between limited dysfunction to different areas within the hippocampus. DG dysfunction affected performance when using unpredictable task parameters. CA3 dysfunction did not result in impairment, even at the longest delays tested.

Indexed as

AnimalsCA3 Region, HippocampalChoice BehaviorConditioning, OperantDentate GyrusMaleMemoryMemory, Short-TermPsychomotor PerformanceRatsReaction TimeCA3Dentate gyrusHippocampusMemory loadRatSpatial working memoryTouchscreen

Identifiers

PMID26220610
PMCPMC4976805

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.