Evidence map›Paper›PMID 26220535›Full record

ArticleStatistical methods in medical research2017

Bayesian hierarchical models for network meta-analysis incorporating nonignorable missingness.

Jing Zhang, Haitao Chu, Hwanhee Hong, Beth A Virnig, Bradley P Carlin

Abstract read
In one paragraph

Article in Statistical methods in medical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Tipping point analysis in network meta-analysis.Research synthesis methods · 2025
    Article
  2. Article
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  4. Article
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  9. Bayesian Network Meta-analysis of Multiple Outcomes in Dental Research.The journal of evidence-based dental practice · 2020
    Article
  10. Article
  11. Article
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  13. Article
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  15. Article
  16. CORR InsightsClinical orthopaedics and related research · 2017
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jing Zhang1 Department of Epidemiology and Biostatistics, University of Maryland, College Park, MD, USA.
Haitao Chu2 Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Hwanhee Hong3 Department of Mental Health, Johns Hopkins University, Baltimore, MD, USA.
Beth A Virnig4 Division of Health Policy and Management, University of Minnesota, Minneapolis, MN, USA.
Bradley P Carlin2 Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA.

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
Research CoreU54MD008620 · NIMHD · UNIVERSITY OF MINNESOTA · PI KONETY, BADRINATH R, SHIKANY, JAMES M · 2013 to 2017
$13.5M
MARYLAND POPULATION RESEARCH CENTERR24HD041041 · NICHD · UNIV OF MARYLAND, COLLEGE PARK · PI RENDALL, MICHAEL S. · 2001 to 2016
$6.6M
Statistical Methods and Software for More Efficient, Ethical, and Affordable ClinR01CA157458 · NCI · UNIVERSITY OF MINNESOTA · PI CARLIN, BRADLEY P · 2012 to 2014
$939k
Bayesian Methods and Software for Patient-Centered Network Meta-Analysis of BinarR21AI103012 · NIAID · UNIVERSITY OF MINNESOTA · PI CHU, HAITAO · 2013 to 2014
$385k
Aiding Effective Decision Making in Dental Research Using Network Meta-analysisR03DE024750 · NIDCR · UNIVERSITY OF MINNESOTA · PI CHU, HAITAO, JOHN, MIKE · 2015 to 2016
$292k
NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA157458NIAID NIH HHS R21 AI103012NICHD NIH HHS R24 HD041041NIDCR NIH HHS R03 DE024750NIMHD NIH HHS U54 MD008620
6 · The paper itself

Abstract

Network meta-analysis expands the scope of a conventional pairwise meta-analysis to simultaneously compare multiple treatments, synthesizing both direct and indirect information and thus strengthening inference. Since most of trials only compare two treatments, a typical data set in a network meta-analysis managed as a trial-by-treatment matrix is extremely sparse, like an incomplete block structure with significant missing data. Zhang et al. proposed an arm-based method accounting for correlations among different treatments within the same trial and assuming that absent arms are missing at random. However, in randomized controlled trials, nonignorable missingness or missingness not at random may occur due to deliberate choices of treatments at the design stage. In addition, those undertaking a network meta-analysis may selectively choose treatments to include in the analysis, which may also lead to missingness not at random. In this paper, we extend our previous work to incorporate missingness not at random using selection models. The proposed method is then applied to two network meta-analyses and evaluated through extensive simulation studies. We also provide comprehensive comparisons of a commonly used contrast-based method and the arm-based method via simulations in a technical appendix under missing completely at random and missing at random.

Indexed as

Bayes TheoremMeta-Analysis as TopicModels, StatisticalData Interpretation, StatisticalHumansStatistics as TopicTreatment OutcomeBayesian hierarchical modelsNetwork meta-analysisnonignorable missingnessselection models

Identifiers

PMID26220535
PMCPMC4731325

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.