ArticleBiomechanics and modeling in mechanobiology2016
Adaptation of active tone in the mouse descending thoracic aorta under acute changes in loading.
Article in Biomechanics and modeling in mechanobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- A computational framework for quantifying blood flow dynamics across myogenically-active cerebral arterial networks.Biomechanics and modeling in mechanobiology · 2025Article
- Mechanisms of aortic dissection: From pathological changes to experimental andProgress in materials science · 2025Article
- A new model for evaluating pressure-induced vascular tone in small cerebral arteries.Biomechanics and modeling in mechanobiology · 2024Article
- Role of smooth muscle activation in the static and dynamic mechanical characterization of human aortas.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Characterization of the active response of a guinea pig carotid artery.Frontiers in bioengineering and biotechnology · 2022Article
- Developmental origins of mechanical homeostasis in the aorta.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Differential biomechanical responses of elastic and muscular arteries to angiotensin II-induced hypertension.Journal of biomechanics · 2021Article
- A Chemomechanobiological Model of the Long-Term Healing Response of Arterial Tissue to a Clamping Injury.Frontiers in bioengineering and biotechnology · 2020Article
- Computational Study of Growth and Remodeling in Ascending Thoracic Aortic Aneurysms Considering Variations of Smooth Muscle Cell Basal Tone.Frontiers in bioengineering and biotechnology · 2020Article
- Fundamental Roles of Axial Stretch in Isometric and Isobaric Evaluations of Vascular Contractility.Journal of biomechanical engineering · 2019Article
- Multiscale and Multiaxial Mechanics of Vascular Smooth Muscle.Biophysical journal · 2017Article
- Isometric Stretch Alters Vascular Reactivity of Mouse Aortic Segments.Frontiers in physiology · 2017Article
- Reduced Biaxial Contractility in the Descending Thoracic Aorta of Fibulin-5 Deficient Mice.Journal of biomechanical engineering · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Arteries can adapt to sustained changes in blood pressure and flow, and it is thought that these adaptive processes often begin with an altered smooth muscle cell activity that precedes any detectable changes in the passive wall components. Yet, due to the intrinsic coupling between the active and passive properties of the arterial wall, it has been difficult to delineate the adaptive contributions of active smooth muscle. To address this need, we used a novel experimental-computational approach to quantify adaptive functions of active smooth muscle in arterial rings excised from the proximal descending thoracic aorta of mice and subjected to short-term sustained circumferential stretches while stimulated with various agonists. A new mathematical model of the adaptive processes was derived and fit to data to describe and predict the effects of active tone adaptation. It was found that active tone was maintained when the artery was adapted close to the optimal stretch for maximal active force production, but it was reduced when adapted below the optimal stretch; there was no significant change in passive behavior in either case. Such active adaptations occurred only upon smooth muscle stimulation with phenylephrine, however, not stimulation with KCl or angiotensin II. Numerical simulations using the proposed model suggested further that active tone adaptation in vascular smooth muscle could play a stabilizing role for wall stress in large elastic arteries.
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