ArticleBMC genomics2015
Transcriptional analysis of susceptible and resistant European corn borer strains and their response to Cry1F protoxin.
Article in BMC genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Immune priming in the insect gut: a dynamic response revealed by ultrastructural and transcriptomic changes.BMC biology · 2025Article
- V-ATPase C Acts as a Receptor forInsects · 2024Article
- A chromosome-level genome assembly of the soybean pod borer: insights into larval transcriptional response to transgenic soybean expressing the pesticidal Cry1Ac protein.BMC genomics · 2024Article
- Genetic mutations linked to field-evolved Cry1Fa-resistance in the European corn borer, Ostrinia nubilalis.Scientific reports · 2023Article
- A Novel Reference for Bt-Resistance Mechanism inInsects · 2021Article
- Article
- Toxicological and molecular profiling of insecticide resistance in a Brazilian strain of fall armyworm resistant to Bt Cry1 proteins.Pest management science · 2021Article
- Response Mechanisms of Invertebrates toMicrobiology and molecular biology reviews : MMBR · 2021Review
- Suppression of Calcineurin Enhances the Toxicity of Cry1Ac toFrontiers in microbiology · 2021Article
- Differences in midgut transcriptomes between resistant and susceptible strains of Chilo suppressalis to Cry1C toxin.BMC genomics · 2020Article
- Article
- Transcriptomic analysis ofBiology open · 2019Article
- Recent progress on the interaction between insects and Bacillus thuringiensis crops.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Transcriptome and Proteome Alternation With Resistance toFrontiers in physiology · 2019Article
- Transcriptome profiling of lentil (Lens culinaris) through the first 24 hours of Ascochyta lentis infection reveals key defence response genes.BMC genomics · 2018Article
- Transcriptomic Responses to Different Cry1Ac Selection Stresses inFrontiers in physiology · 2018Article
- Article
- Down-regulation of aminopeptidase N and ABC transporter subfamily G transcripts in Cry1Ab and Cry1Ac resistant Asian corn borer,International journal of biological sciences · 2017Article
- Intestinal regeneration as an insect resistance mechanism to entomopathogenic bacteria.Current opinion in insect science · 2016Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite a number of recent reports of insect resistance to transgenic crops expressing insecticidal toxins from Bacillus thuringiensis (Bt), little is known about the mechanism of resistance to these toxins. The purpose of this study is to identify genes associated with the mechanism of Cry1F toxin resistance in European corn borer (Ostrinia nubilalis Hübner). For this, we compared the global transcriptomic response of laboratory selected resistant and susceptible O. nubilalis strain to Cry1F toxin. We further identified constitutive transcriptional differences between the two strains.
resultsAn O. nubilalis midgut transcriptome of 36,125 transcripts was assembled de novo from 106 million Illumina HiSeq and Roche 454 reads and used as a reference for estimation of differential gene expression analysis. Evaluation of gene expression profiles of midgut tissues from the Cry1F susceptible and resistant strains after toxin exposure identified a suite of genes that responded to the toxin in the susceptible strain (n = 1,654), but almost 20-fold fewer in the resistant strain (n = 84). A total of 5,455 midgut transcripts showed significant constitutive expression differences between Cry1F susceptible and resistant strains. Transcripts coding for previously identified Cry toxin receptors, cadherin and alkaline phosphatase and proteases were also differentially expressed in the midgut of the susceptible and resistant strains.
conclusionsOur current study provides a valuable resource for further molecular characterization of Bt resistance and insect response to Cry1F toxin in O. nubilalis and other pest species.
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