Evidence map›Paper›PMID 26220140›Full record

ArticleScientific reports2015

In vitro and in vivo host range of Anopheles gambiae densovirus (AgDNV).

Yasutsugu Suzuki, Tapan K Barik, Rebecca M Johnson, Jason L Rasgon

Abstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Infectious transgenesis in arthropods.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. bioRxiv : the preprint server for biology · 2023
    Article
  6. Article
  7. Symbiotic Interactions Between Mosquitoes and Mosquito Viruses.Frontiers in cellular and infection microbiology · 2021
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yasutsugu SuzukiDepartment of Entomology, Center for Infectious Disease Dynamics and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, 16802, United States of America.
Tapan K Barik1] Department of Entomology, Center for Infectious Disease Dynamics and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, 16802, United States of America [2] Post Graduate Department of Zoology, Berhampur University, Berhampur, Odisha 760007, India.
Rebecca M JohnsonDepartment of Entomology, Center for Infectious Disease Dynamics and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, 16802, United States of America.
Jason L RasgonDepartment of Entomology, Center for Infectious Disease Dynamics and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania, 16802, United States of America.

Funding

Genetic basis of WNV vector competence in Culex tarsalisR01AI067371 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI RASGON, JASON L · 2007 to 2011
$2.0M
Wolbachia-induced enhancement of human arboviral pathogensR01AI116636 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI RASGON, JASON L · 2016 to 2020
$1.9M
Efficient site-specific genetic engineering of the Anopheles gambiae genomeR21AI088311 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI RASGON, JASON L · 2010 to 2011
$439k
ReMOT Control of mosquito transgenesisR21AI111175 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI RASGON, JASON L · 2014 to 2015
$411k
Wolbachia-induced enhancement of human arboviral pathogensR56AI116636 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI RASGON, JASON L · 2015 to 2015
$368k
NIAID NIH HHS R01 AI067371NIAID NIH HHS R01AI067371NIAID NIH HHS R01 AI116636NIAID NIH HHS R21 AI088311NIAID NIH HHS R21AI088311NIAID NIH HHS R21 AI111175NIAID NIH HHS R21AI111175NIAID NIH HHS R56 AI116636NIAID NIH HHS R56AI116636
6 · The paper itself

Abstract

AgDNV is a powerful gene transduction tool and potential biological control agent for Anopheles mosquitoes. Using a GFP reporter virus system, we investigated AgDNV host range specificity in four arthropod cell lines (derived from An. gambiae, Aedes albopictus and Drosophila melanogaster) and six mosquito species from 3 genera (An. gambiae, An. arabiensis, An. stephensi, Ae. albopictus, Ae. aegypti and Culex tarsalis). In vitro, efficient viral invasion, replication and GFP expression was only observed in MOS55 An. gambiae cells. In vivo, high levels of GFP were observed in An. gambiae mosquitoes. Intermediate levels of GFP were observed in the closely related species An. arabiensis. Low levels of GFP were observed in An. stephensi, Ae. albopictus, Ae. aegypti and Cx. tarsalis. These results suggest that AgDNV is a specific gene transduction tool for members of the An. gambiae species complex, and could be potentially developed into a biocontrol agent with minimal off-target effects.

Indexed as

AedesAnimalsAnophelesCell LineCulexDensovirusDrosophila melanogasterGreen Fluorescent ProteinsHost SpecificityInsect VectorsMicroscopy, FluorescenceSpecies SpecificityGreen Fluorescent Proteins

Identifiers

PMID26220140
PMCPMC4518260

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.