ArticleClinical research in cardiology : official journal of the German Cardiac Society2016
Comorbid renal tubular damage and hypoalbuminemia exacerbate cardiac prognosis in patients with chronic heart failure.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Anemia of Renal Tubular Damage and Mortality in the General Population: The Yamagata (Takahata) study.Internal medicine (Tokyo, Japan) · 2026Article
- Assessment of right ventricular dysfunction and its association with excess risk of cardiovascular events in patients undergoing maintenance hemodialysis.Renal failure · 2024Article
- Renal tubular damage and clinical outcome in heart failure with preserved ejection fraction and chronic kidney disease.ESC heart failure · 2023Article
- Left Ventricular Diastolic Dysfunction in Chronic Kidney Disease Patients Not Treated with Dialysis.Nutrients · 2022Article
- Association of malnutrition with renal dysfunction and clinical outcome in patients with heart failure.Scientific reports · 2022Article
- Association Between Serum Albumin Levels and Obesity and Risk of Developing Chronic Kidney Disease Using Data from the Korean Multi-Rural Communities Cohort (MRCohort) Population Database.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Serum albumin concentration and risk of end-stage renal disease: the REGARDS study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2018Article
- Radial access protects from contrast media induced nephropathy after cardiac catheterization procedures.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Observational
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundRenal tubular damage (RTD) and hypoalbuminemia are risks for poor prognosis in patients with chronic heart failure (CHF). Renal tubules play a pivotal role in amino acid and albumin reabsorption, which maintain serum albumin levels. The aims of the present study were to (1) examine the association of RTD with hypoalbuminemia, and (2) assess the prognostic importance of comorbid RTD and hypoalbuminemia in patients with CHF. METHODS AND
resultsWe measured N-acetyl-β-D-glucosamidase (NAG) levels and the urinary β2-microglobulin to creatinine ratio (UBCR) in 456 patients with CHF. RTD was defined as UBCR ≥ 300 μg/g or NAG ≥ 14.2 U/g. There were moderate correlations between RTD markers and serum albumin (NAG, r = -0.428, P < 0.0001; UBCR, r = -0.399, P < 0.0001). Multivariate logistic analysis showed that RTD was significantly related to hypoalbuminemia in patients with CHF. There were 134 cardiac events during a median period of 808 days. The comorbidity of RTD and hypoalbuminemia was increased with advancing New York Heart Association functional class. Multivariate Cox proportional hazard regression analysis showed that the presence of RTD and hypoalbuminemia was associated with cardiac events. The net reclassification index was significantly improved by adding RTD and hypoalbuminemia to the basic risk factors.
conclusionComorbid RTD and hypoalbuminemia are frequently observed and increase the risk for extremely poor outcome in patients with CHF.
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