ArticleHuman brain mapping2015
Dysfunctional amygdala activation and connectivity with the prefrontal cortex in current cocaine users.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Common and separable neural alterations in substance use disorders: A coordinate-based meta-analyses of functional neuroimaging studies in humans.Human brain mapping · 2020Pooled it
- Oxytocin moderates fMRI connectivity and response to implicit threat processing in cocaine use disorder.Psychoneuroendocrinology · 2025Trial
- Neuroimaging as the 'missing link' for preclinical to clinical translation: an example using N-acetylcysteine among individuals with cocaine- and opioid-use disorders receiving methadone treatment.Psychopharmacology · 2026Article
- From Neuroadaptation to Neuroprogression: Rethinking Chronic Cocaine Exposure Through a Model of Cocaine-Related Cerebropathy.Journal of clinical medicine · 2026Article
- Magnetic Resonance Imaging Textural Changes Are More Sensitive Than Volumetric Changes in the Amygdala of Cocaine Use Disorder Patients.NMR in biomedicine · 2026Article
- Structural Cerebellar and Lateral Frontoparietal Networks are altered in CUD: An SBM Analysis.Addiction biology · 2025Article
- Exercise Influences the Brain's Metabolic Response to Chronic Cocaine Exposure in Male Rats.Journal of personalized medicine · 2024Article
- The therapeutic potential of low-intensity focused ultrasound for treating substance use disorder.Frontiers in psychiatry · 2024Review
- Oxytocin moderates corticolimbic social stress reactivity in cocaine use disorder and healthy controls.Comprehensive psychoneuroendocrinology · 2022Article
- Sex-specific effects of cigarette smoking on caudate and amygdala volume and resting-state functional connectivity.Brain imaging and behavior · 2021Article
- Effects of Recreational GHB Use and Multiple GHB-Induced Comas on Brain Structure and Impulsivity.Frontiers in psychiatry · 2020Article
- Efficacy of Invasive and Non-Invasive Brain Modulation Interventions for Addiction.Neuropsychology review · 2019Review
- Preliminary development of a neuroimaging paradigm to examine neural correlates of relationship conflict.Psychiatry research. Neuroimaging · 2019Article
- Influence of Gamma-Hydroxybutyric Acid-Use and Gamma-Hydroxybutyric Acid-Induced Coma on Affect and the Affective Network.European addiction research · 2019Article
- The importance of considering polysubstance use: lessons from cocaine research.Drug and alcohol dependence · 2018Review
- Enhanced Amygdala-Striatal Functional Connectivity during the Processing of Cocaine Cues in Male Cocaine Users with a History of Childhood Trauma.Frontiers in psychiatry · 2018Article
- Dynamic network dysfunction in cocaine dependence: Graph theoretical metrics and stop signal reaction time.NeuroImage. Clinical · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesStimulant use is associated with increased anxiety and a single administration of dexamphetamine increases amygdala activation to biologically salient stimuli in healthy individuals. Here, we investigate how current cocaine use affects amygdala activity and amygdala connectivity with the prefrontal cortex in response to biologically salient stimuli in an emotional face matching task (EFMT). EXPERIMENTAL
designAmygdala activity and amygdala connectivity during the EFMT were assessed in 51 cocaine using males and 32 non-drug-using healthy males using functional magnetic resonance imaging (fMRI). Within the cocaine use group, we explored whether amygdala activation was associated with age of first use of cocaine and duration of cocaine use to distinguish between amygdala activation alterations as a cause or a consequence of cocaine use. PRINCIPAL OBSERVATIONS: We observed hyperactivity of the amygdala, thalamus, and hippocampus and reduced amygdala connectivity with the anterior cingulate gyrus in response to angry and fearful facial expressions in current cocaine users compared to controls. Increased amygdala activation was independently associated with earlier age of first cocaine use and with longer exposure to cocaine.
conclusionsOur findings suggest that amygdala hyperactivity to biologically salient stimuli may represent a risk factor for an early onset of cocaine use and that prolonged cocaine use may further sensitize amygdala activation. High amygdala activation to emotional face processing in current cocaine users may result from low prefrontal control of the amygdala response to such stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.