ArticleJournal of experimental & clinical cancer research : CR2015
Primitive sarcoma of the breast: new insight on the proper surgical management.
Article in Journal of experimental & clinical cancer research : CR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Fat necrosis in the Breast: A systematic review of clinical.Lipids in health and disease · 2019Pooled it
- FREM1 serves as a novel therapeutic target in breast cancer through basement membrane-based prognostic modeling with integrated bioinformatics and experimental validation.Discover oncology · 2025Article
- Malignant Mesenchymal Tumors of the Breast: Current Challenges and New Perspectives on Primary Sarcomas and Malignant Phyllodes Tumors.Life (Basel, Switzerland) · 2025Review
- Primary dedifferentiated liposarcoma of the breast: A case report.Clinical case reports · 2022Article
- Construction and validation of a nomogram to predict overall survival in patients with breast sarcoma.Frontiers in oncology · 2022Article
- Nomogram models for stratified prediction of axillary lymph node metastasis in breast cancer patients (cN0).Frontiers in endocrinology · 2022Article
- Giant chondroid lipoma of the breast: A case report and literature review.Experimental and therapeutic medicine · 2021Article
- Postoperative Yanghe decoction regimen improves outcomes for idiopathic granulomatous mastitis: A retrospective cohort study.Medicine · 2020Article
- A case of primary breast angiosarcoma with multiple discontinuous small lesions.Surgical case reports · 2019Article
- Second-harmonic patterned polarization-analyzed reflection confocal microscopy of stromal collagen in benign and malignant breast tissues.Scientific reports · 2018Article
- Magnetic Resonance Imaging after Breast Oncoplastic Surgery: An Update.Breast care (Basel, Switzerland) · 2017Review
- Primary breast chondrosarcoma: Imaging and pathological findings.European journal of radiology open · 2017Article
- Oncoplastic central quadrantectomies.Gland surgery · 2016Review
- A modified sentinel node and occult lesion localization (SNOLL) technique in non-palpable breast cancer: a pilot study.Journal of experimental & clinical cancer research : CR · 2015Article
- A dedifferentiated rare primary breast liposarcoma - case report and literature review.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
- Use of loupes magnification and microsurgical technique in thyroid surgery: ten years experience in a single center.Il Giornale di chirurgiaArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimitive sarcoma of the breast is a rare and challenging disease at high risk of recurrence and with poor prognosis. There are controversies in the diagnosis and management of such solid tumor due to its rarity and heterogeneity. This sarcoma is poorly responsive to both chemotherapy and radiotherapy, thus, surgery is the first and most important therapeutic approach. However, given the rarity of this type tumor it has not be possible to standardize unique guidelines for the proper surgical strategy to adopt. Here, we performed a retrospective study of new 10 cases of primitive sarcoma of the breast that underwent either mastectomy or a more conservative quadrantectomy, in the attempt to better standardize correct surgical indications.
methodsTen new cases of primitive sarcoma of the breast were registered between 2002 and 2012 and constituted the study group. They underwent either mastectomy or quadrantectomy and the clinical, prognostic and survival characteristics after surgery were analysed.
resultsWithin the group of patients treated with mastectomy, two had metastasis and died because of that. Among the five patients treated with quadrantectomy four are alive and free of disease after 3 to 5 years follow-up, while the patient with sarcoma arising in pregnancy, although is still alive, developed lung metastases four years after surgery.
conclusionsThe first and most important therapeutic approach to primary sarcomas of the breast is surgical which has the purpose to achieve radical tumor excision to prevent local recurrence and skip metastases. However, given the rarity of the condition and the consequent small number of cases in this, like in similar studies, it is not possible to draw any definitive conclusions and further studies with larger numbers are necessary. However it would appear that performing a larger procedure such as mastectomy rather than performing a more limited one such as a quadrantectomy, has no advantage in terms of overall prognosis.
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