ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016
Association Between Vestibular and Cognitive Function in U.S. Adults: Data From the National Health and Nutrition Examination Survey.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
- The role of motivation factors in exergame interventions for fall prevention in older adults: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Impact of vestibular rehabilitation therapy on quality of life and cognitive function in individuals with chronic dizziness or vertigo.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Trial
- Using the gait disorientation test to measure spatial navigation in children with cochlear implants.International journal of pediatric otorhinolaryngology · 2025Article
- Associations Between Vestibular Function and White Matter Microstructure in Healthy Older Adults.medRxiv : the preprint server for health sciences · 2025Article
- The Inner Ear and Aging Brain: A Cross-Sectional Study of Vestibular Function and Morphometric Variations in the Entorhinal and Trans-Entorhinal Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Effects of Hearing Aids on Static and Subjective Balance in Patients With Hearing Loss: A Pilot Study.Journal of audiology & otology · 2025Article
- Age-related hearing loss and balance disorders: analysis of interactions and clinical implications in older persons. Systematic review and meta-analysis.Frontiers in aging · 2025Review
- Cognitive deficits in patients with peripheral vestibular dysfunction.European journal of neurology · 2025Article
- Vestibular perceptual learning improves self-motion perception, posture, and gait in older adults.Communications biology · 2024Article
- Internal Psychometric Validation of an International Burden of Illness Survey for Idiopathic Multicentric Castleman Disease.Oncology and therapy · 2024Article
- Psychological aspects of vestibular disorders: a national survey of clinical practice.The Journal of laryngology and otology · 2024Article
- Ten-year association between change in speech-in-noise recognition and falls due to balance problems: a longitudinal cohort study.BMC public health · 2024Article
- Vestibular Function is Associated with Prefrontal and Sensorimotor Cortical Gray Matter Volumes in a Cross-Sectional Study of Healthy, Older Adults.Aperture neuro · 2024Article
- Cognition in vestibular disorders: state of the field, challenges, and priorities for the future.Frontiers in neurology · 2024Review
- Effects of aging on otolith morphology and functions in mice.Frontiers in neuroscience · 2024Article
- Functional, Morphological and Molecular Changes Reveal the Mechanisms Associated with Age-Related Vestibular Loss.Biomolecules · 2023Article
- The interplay between cognition, functional and dual-task gait in persons with a vestibular disorder versus healthy controls.Scientific reports · 2023Observational
- Increased roll tilt thresholds are associated with subclinical postural instability in asymptomatic adults aged 21 to 84 years.Frontiers in aging neuroscience · 2023Article
- Vestibular contribution to path integration deficits in 'at-genetic-risk' for Alzheimer's disease.PloS one · 2023Article
- Navigation strategies in patients with vestibular loss tested in a virtual reality T-maze.Journal of neurology · 2022Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundVestibular function declines with age, and emerging evidence suggests that vestibular loss is associated with cognitive impairment. Whether vestibular dysfunction is associated with age-related cognitive decline is unknown.
methodsWe used data from the 1999-2002 National Health and Nutrition Examination Surveys to evaluate the influence of vestibular function on cognitive performance in a nationally representative sample of U.S. adults aged ≥60 years (n = 1,303). Vestibular function was measured with the modified Romberg test, and cognitive function was measured by the digit symbol substitution (DSS) score test. We also developed structural equation models (SEMs) to explore whether vestibular dysfunction and associated cognitive impairment mediate the effect of age on falls and activities of daily living (ADL) difficulty.
resultsVestibular dysfunction was present in 58% of the study population. In multivariate analyses, vestibular dysfunction was associated with a 3.4-point lower DSS score (95% confidence interval: -5.2, -1.6; p < .0001), equivalent to the effect of 5 years of age. Vestibular dysfunction was also associated with a significantly higher odds of ADL difficulty (p = .001), and with a 2.6-fold increase in the odds of falling (p = .017). SEMs suggested that vestibular function mediates 14.3% of the effect of age on cognitive performance. Further SEMs suggested that lower cognitive performance mediates the association between vestibular loss and ADL difficulty as well as falls.
conclusionsThis study suggests that vestibular dysfunction partially mediates the association between age and cognitive impairment. Moreover, the cognitive impairment that results from vestibular loss may contribute to ADL difficulty and falls in older individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.