ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016
The Expression Changes of Inflammasomes in the Aging Rat Kidneys.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Calorie Restriction Modulates Gene Expression of Il19 and Il24 during Renal Aging.Annals of geriatric medicine and research · 2026Article
- Inhibition of caspase-1 by ginsenoside Rg1 ameliorates d-gal-induced renal aging and injury through suppression of oxidative stress and inflammation.Renal failure · 2025Article
- The effect of NF-kB and MAPK mediated Proinflammatory microenvironment on renal aging and amyloid deposition in elder rats.Scientific reports · 2025Article
- Immunosenescence and the Geriatric Giants: Molecular Insights into Aging and Healthspan.Medical sciences (Basel, Switzerland) · 2025Review
- Kidney Aging and Chronic Kidney Disease.International journal of molecular sciences · 2024Review
- cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging.Frontiers in immunology · 2023Review
- The process of ovarian aging: it is not just about oocytes and granulosa cells.Journal of assisted reproduction and genetics · 2022Review
- Association of Tim-3/Gal-9 Axis with NLRC4 Inflammasome in Glioma Malignancy: Tim-3/Gal-9 Induce the NLRC4 Inflammasome.International journal of molecular sciences · 2022Article
- Endothelial Dysfunction Accelerates Impairment of Mitochondrial Function in Ageing Kidneys via Inflammasome Activation.International journal of molecular sciences · 2021Article
- Activation of the NLRC4 inflammasome in renal tubular epithelial cell injury in diabetic nephropathy.Experimental and therapeutic medicine · 2021Article
- Aging and Renal Disease: Old Questions for New Challenges.Aging and disease · 2021Review
- Evaluation of inflammation and follicle depletion during ovarian ageing in mice.Scientific reports · 2021Article
- ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities - Role of gut microbiota dysbiosis.Ageing research reviews · 2020Review
- Inflammasome activation in podocytes: a new mechanism of glomerular diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Review
- Network Pharmacology-Based Strategy to Investigate the Pharmacological Mechanisms ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Hyperglycemia-induced inflamm-aging accelerates gingival senescence via NLRC4 phosphorylation.The Journal of biological chemistry · 2019Article
- Flavonoids: Broad Spectrum Agents on Chronic Inflammation.Biomolecules & therapeutics · 2019Review
- Article
- Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.Nature medicine · 2017Article
- Renal Aging: Causes and Consequences.Journal of the American Society of Nephrology : JASN · 2017Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms of kidney aging are not yet clear. Studies have shown that immunological inflammation is related to kidney aging. Inflammasomes are important components of innate immune system in the body. However, the function of inflammasomes and their underlying mechanisms in renal aging remain unclear. In this study, for the first time, we systematically investigated the role of the inflammasomes and the inflammatory responses activated by inflammasomes during kidney aging. We found that during kidney aging, the expression levels of the molecules associated with the activation of inflammasomes, including toll-like receptor-4 and interleukin-1 receptor (IL-1R), were significantly increased; their downstream signaling pathway molecule interleukin-1 receptor-associated kinase-4 (IRAK4) was markedly activated (Phospho-IRAK4 was obviously increased); the nuclear factor-κB (NF-κB) signaling pathway was activated (the activated NF-κB pathway molecules Phospho-IKKβ, Phospho-IκBα, and Phospho-NF-κBp65 were significantly elevated); the levels of the inflammasome components NOD-like receptor P3 (NLRP3), NLRC4, and pro-caspase-1 were prominently upregulated; and the proinflammatory cytokines IL-1β and IL-18 were notably increased in the kidneys of 24-month-old (elderly group) rats. These results showed that inflammasomes are markedly activated during the renal aging process and might induce inflamm-aging by promoting the maturation and secretion of the proinflammatory cytokines IL-1β and IL-18.
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