Evidence map›Paper›PMID 26219695›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2015

Association of immune response to endothelial cell growth factor with early disseminated and late manifestations of Lyme disease but not posttreatment Lyme disease syndrome.

Kevin S Tang, Mark S Klempner, Gary P Wormser, Adriana R Marques, Armin Alaedini

Open access · bronzeAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Persistent Symptoms After Treatment of Lyme Disease.Infectious disease clinics of North America · 2022
    Review
  2. Review
  3. Expression of C-Reactive Protein and Serum Amyloid A in Early to Late Manifestations of Lyme Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Kevin S TangDepartment of Medicine, Columbia University Medical Center, New York, New York.
Mark S KlempnerMassBiologics, University of Massachusetts Medical School, Boston.
Gary P WormserDivision of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, New York.
Adriana R MarquesLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Armin AlaediniDepartment of Medicine, Columbia University Medical Center, New York, New York.
Columbia University Irving Medical Center · USNational Institutes of Health Clinical Center · USNew York Medical College · USUniversity of Massachusetts Chan Medical School · US

Funding

Assessment Of Patients With Borrelia InfectionZIAAI000695 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MARQUES, ADRIANA R · 2009 to 2025
$8.8M
CLINICAL STUDIES OF CHRONIC LYME DISEASE-266965308N01AI065308 · NIAID · TUFTS MEDICAL CENTER · 1996 to 2004
$810k
Immunologic mechanisms in post-Lyme disease syndromeR56AI093763 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALAEDINI, ARMIN · 2011 to 2011
$360k
Intramural NIH HHSNIAID NIH HHS N01 AI065308NIAID NIH HHS R56 AI093763NIAID NIH HHS R56AI093763
6 · The paper itself

Abstract

Endothelial cell growth factor has been recently proposed as a potential autoantigen in manifestations of Lyme disease that are thought to involve immune-mediated mechanisms. Our findings indicate that a humoral immune response to this protein is not associated with posttreatment Lyme disease syndrome.

Indexed as

AdultAgedAntibodies, BacterialAutoantibodiesAutoantigensBorrelia burgdorferi GroupFemaleHumansImmunity, HumoralImmunoglobulin GLyme DiseaseMaleMiddle AgedSyndromeAntibodies, BacterialAutoantibodiesAutoantigensImmunoglobulin GantibodyBorrelia burgdorferiendothelial cell growth factorLyme diseaseposttreatment Lyme disease syndrome

Identifiers

PMID26219695
PMCPMC4643484
OpenAlexW2272320738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.