ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2016
Alzheimer's disease--subcortical vascular disease spectrum in a hospital-based setting: Overview of results from the Gothenburg MCI and dementia studies.
Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
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- Low serum HDL-cholesterol is associated with increased risk of the subcortical small vessel type of dementia.Cerebral circulation - cognition and behavior · 2024Article
- Diagnostic Performance of Cerebrospinal Fluid Neurofilament Light Chain and Soluble Amyloid-β Protein Precursor β in the Subcortical Small Vessel Type of Dementia.Journal of Alzheimer's disease : JAD · 2023Article
- Recognizing Atypical Presentations of Alzheimer's Disease: The Importance of CSF Biomarkers in Clinical Practice.Diagnostics (Basel, Switzerland) · 2022Article
- Blood-brain barrier dysfunction and reduced cerebrospinal fluid levels of soluble amyloid precursor protein-β in patients with subcortical small-vessel disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Low Serum Insulin-like Growth Factor-I Is Associated with Decline in Hippocampal Volume in Stable Mild Cognitive Impairment but not in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2022Article
- Article
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- Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in the Era of Disease-Modifying Treatments.Brain sciences · 2021Article
- Evaluation of the ATN model in a longitudinal memory clinic sample with different underlying disorders.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort.Journal of Alzheimer's disease : JAD · 2020Article
- Characteristic Biomarker and Cognitive Profile in Incipient Mixed Dementia.Journal of Alzheimer's disease : JAD · 2020Article
- Peri-Infarct Upregulation of the Oxytocin Receptor in Vascular Dementia.Journal of neuropathology and experimental neurology · 2019Article
- The Full Spectrum of Alzheimer's Disease Is Rooted in Metabolic Derangements That Drive Type 3 Diabetes.Advances in experimental medicine and biology · 2019Review
- The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics.Alzheimer's research & therapy · 2018Article
- Cognitive medicine - a new approach in health care science.BMC psychiatry · 2018Article
- Delineation of two intracranial areas and the perpendicular intracranial width is sufficient for intracranial volume estimation.Insights into imaging · 2018Article
- Update on Vascular Cognitive Impairment Associated with Subcortical Small-Vessel Disease.Journal of Alzheimer's disease : JAD · 2018Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
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Abstract
The ability to discriminate between Alzheimer's disease (AD), subcortical vascular disease, and other cognitive disorders is crucial for diagnostic purposes and clinical trial outcomes. Patients with primarily subcortical vascular disease are unlikely to benefit from treatments targeting the AD pathogenic mechanisms and vice versa. The Gothenburg mild cognitive impairment (MCI) and dementia studies are prospective, observational, single-center cohort studies suitable for both cross-sectional and longitudinal analysis that outline the cognitive profiles and biomarker characteristics of patients with AD, subcortical vascular disease, and other cognitive disorders. The studies, the first of which started in 1987, comprise inpatients with manifest dementia and patients seeking care for cognitive disorders at an outpatient memory clinic. This article gives an overview of the major published papers (neuropsychological, imaging/physiology, and neurochemical) of the studies including the ongoing Gothenburg MCI study. The main findings suggest that subcortical vascular disease with or without dementia exhibit a characteristic neuropsychological pattern of mental slowness and executive dysfunction and neurochemical deviations typical of white matter changes and disturbed blood-brain barrier function. Our findings may contribute to better healthcare for this underrecognized group of patients. The Gothenburg MCI study has also published papers on multimodal prediction of dementia, and cognitive reserve.
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