ArticleMolecular biology and evolution2015
Divergence in Enzymatic Activities in the Soybean GST Supergene Family Provides New Insight into the Evolutionary Dynamics of Whole-Genome Duplicates.
Article in Molecular biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 73 citations in OpenAlex.
- Overexpression of SiGSTU24 enhances salt tolerance in transgenic Arabidopsis.BMC plant biology · 2025Article
- Glutathione S-transferase in mediating adaptive responses of oats (Avena sativa) to osmotic and cadmium stress: genome-wide analysis.BMC plant biology · 2025Article
- Decoding the saline-alkaline tolerance nexus in soybean: a dual-method evaluation model coupled with co-expression networks identifies core regulatory genes.Frontiers in plant science · 2025Article
- Overlooked and misunderstood: can glutathione conjugates be clues to understanding plant glutathione transferases?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Complex evolutionary patterns within the tubulin gene family of ciliates, unicellular eukaryotes with diverse microtubular structures.BMC biology · 2024Article
- Genome-Wide Identification of Glutathione S-Transferase Family fromInternational journal of molecular sciences · 2024Article
- Genome-wide identification and characterization of glutathione3 Biotech · 2023Article
- Genome-Wide Identification and Expression Profiling of GlutathionePlants (Basel, Switzerland) · 2023Article
- Regulatory and functional divergence among members ofFrontiers in plant science · 2023Article
- RNA-seq Gene Profiling Reveals Transcriptional Changes in the Late Phase during Compatible Interaction between a Korean Soybean Cultivar (Glycine max cv. Kwangan) and Pseudomonas syringae pv. syringae B728a.The plant pathology journal · 2022Article
- Rhamnosyltransferases involved in the biosynthesis of flavone rutinosides in Chrysanthemum species.Plant physiology · 2022Article
- Computational insights into diverse aspects of glutathione S-transferase gene family in Papaver somniferum.Journal of plant research · 2022Article
- Genome-wide expression analysis of carboxylesterase (CXE) gene family implies GBCXE49 functional responding to alkaline stress in cotton.BMC plant biology · 2022Article
- BnaA03.MKK5-BnaA06.MPK3/BnaC03.MPK3 Module Positively Contributes toPlants (Basel, Switzerland) · 2022Article
- Identification and Structure Analysis ofFrontiers in genetics · 2022Article
- Identification of glutathione transferase gene associated with partial resistance to Sclerotinia stem rot of soybean using genome-wide association and linkage mapping.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Horizontally acquired cysteine synthase genes undergo functional divergence in lepidopteran herbivores.Heredity · 2021Article
- Comparative Analysis of the Glutathione S-Transferase Gene Family of FourInternational journal of genomics · 2021Article
- Genome-wide survey of soybean papain-like cysteine proteases and their expression analysis in root nodule symbiosis.BMC plant biology · 2020Article
- Glutathione S-transferase: a versatile protein family.3 Biotech · 2020Review
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whole-genome duplication (WGD), or polyploidy, is a major force in plant genome evolution. A duplicate of all genes is present in the genome immediately following a WGD event. However, the evolutionary mechanisms responsible for the loss of, or retention and subsequent functional divergence of polyploidy-derived duplicates remain largely unknown. In this study we reconstructed the evolutionary history of the glutathione S-transferase (GST) gene family from the soybean genome, and identified 72 GST duplicated gene pairs formed by a recent Glycine-specific WGD event occurring approximately 13 Ma. We found that 72% of duplicated GST gene pairs experienced gene losses or pseudogenization, whereas 28% of GST gene pairs have been retained in the soybean genome. The GST pseudogenes were under relaxed selective constraints, whereas functional GSTs were subject to strong purifying selection. Plant GST genes play important roles in stress tolerance and detoxification metabolism. By examining the gene expression responses to abiotic stresses and enzymatic properties of the ancestral and current proteins, we found that polyploidy-derived GST duplicates show the divergence in enzymatic activities. Through site-directed mutagenesis of ancestral proteins, this study revealed that nonsynonymous substitutions of key amino acid sites play an important role in the divergence of enzymatic functions of polyploidy-derived GST duplicates. These findings provide new insights into the evolutionary and functional dynamics of polyploidy-derived duplicate genes.
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